ID A0A3Q1HD40_ANATE Unreviewed; 743 AA.
AC A0A3Q1HD40;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Nuclear receptor subfamily 4 group A member 2 {ECO:0000256|ARBA:ARBA00019630};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000002773.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000002773.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR AlphaFoldDB; A0A3Q1HD40; -.
DR STRING; 64144.ENSATEP00000002773; -.
DR Ensembl; ENSATET00000002801.2; ENSATEP00000002773.1; ENSATEG00000001971.2.
DR GeneTree; ENSGT00950000183038; -.
DR InParanoid; A0A3Q1HD40; -.
DR OrthoDB; 5395768at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0001780; P:neutrophil homeostasis; IEA:Ensembl.
DR CDD; cd06969; NR_DBD_NGFI-B; 1.
DR CDD; cd06945; NR_LBD_Nurr1_like; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR003070; NR4A1-3.
DR InterPro; IPR003073; NR4A2.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24085:SF2; NUCLEAR RECEPTOR SUBFAMILY 4 GROUP A MEMBER 3; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR01284; NUCLEARECPTR.
DR PRINTS; PR01287; NURRNUCRCPTR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 404..479
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 506..741
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 123..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 80839 MW; 355493C201922658 CRC64;
MRECVCICTR VCDRKGALSA MKSACHGASC CSKTELETHG AQESTGSVSG PTLHNFSISL
SLWMNPDQAN TVVIRGKRND GLEAVAQTAF IKVVTFVDTG SEERAQPSSE PRRLDTLSAT
HAESSLLQEP CPSRSHATPQ SRTPSTIQRE AISPDMPCVQ AQYGPAPPGS AYSGQSFSYQ
SDSYSSDLMT PDYTKLDLGG GEISAAATTS LPSFNVFVEG SYEPKSSCLY QMPTHRPTIK
KEEESYPTAP PLEAMSSSTM YFKQSPPSTP TTPSLPPQPG TSFLWEEHSL APPHSHSLGS
GLETGPLKSP RFPHFYQHSP PHSGGSVSGY ESLGGGLVRT SSSSSSSSSS ISHPHGPPLE
QPMYPLHRGA GGSSLAFRSL ALGPCGPLLG DSLPSPPPRG PQGEGTCAVC GDNAACQHYG
VRTCEGCKGF FKRTVQKNAK YVCLASKSCP VDKRRRNRCQ YCRFQKCLSV GMVKEVVRTD
SLKGRRGRLP SKPKSPLQTE TSPPSPPLSL LSALLRAYSH STPRDLDYSQ FSAADPPSST
SDAEHIQLFY RLLTISMETT RCWAERLPGF CELQRDDQNL LIDSAFLELF VLRLAHRSML
SEDKLVFCNG LVLHRFQCLR GFGEWLDSIR DFSNHLQSLN LDASAFACLA ALVLLTEQVP
GLKDSKRVEE LQNKVICCLR DHLGCGPSSS SSKSAPPLSR ILGLRAELRS QRTQGLQRIF
YLKLEDLVPP PPLIDRFLDT LPY
//
