ID   A0A3Q1HEI8_ANATE        Unreviewed;       837 AA.
AC   A0A3Q1HEI8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A1 {ECO:0000313|Ensembl:ENSATEP00000003318.2};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000003318.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000003318.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A3Q1HEI8; -.
DR   Ensembl; ENSATET00000003348.2; ENSATEP00000003318.2; ENSATEG00000002275.2.
DR   GeneTree; ENSGT00950000182881; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF91; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        401..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        547..568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        574..598
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        639..659
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        769..793
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..121
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   837 AA;  95764 MW;  8A996EFE6C6DED65 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG EIGMVQFRDL NPDVNAFQRK FVNEVRRCEE
     MDRKLRFVEK EINKANIPIV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILRRTQQFFD EVSMEDPSLL EESSTLLEPH EVNRGAALRL GFVAGVIGRE
     RIPTFERMLW RVCRGNVFLR QAEIEDPLED PATSDQVHKS VFIIFFQGDQ LKNRVKKICE
     GFRATLYPCP ETPQERKEML AGVNARIDDL QMVLNQTEDH RQRVLQAAAK TVRVWFIKVR
     KMKAIYHTLN LCNIDVTQKC LIAEVWCPVS ELDSIQFALR RGTEKSGSTV PSILNRMQTK
     QTPPTFNKTN KFTTGFQNIV DAYGIGNYRE MNPAPYTIIT FPFLFAVMFG DLGHGLLMTC
     GALFLVIRER RLIAQKNDNE MFNMVFSGRY IILMMGLFSI YTGTIYNDCF SKALNVYGSS
     WSVRPMFNPQ VGGNWTPDTL AGNNLLQLDP AVPGVFNGPY PIGIDPIWAI SSNKLTFLNS
     FKMKMSVILG VIHMLFGVSL SLFNHLYFKK PLNIYLEFIP ELVFMSSLFG YLIILVFYKW
     TTYNVFMSKD APSLLITFIN MFLFSYNDPT NKPLYKGQMI LQSLLVILAL ACVPCMLIVK
     PLMLRRQHLQ KQNQGVQNFG GVTVRNGPTD DQAEIIQHDQ LEQQTEEEHE FDFADLAVHQ
     AIHTIEYCLG CISNTASYLR LWALSLAHAQ LSEVLWTMVM HIGLSSRSIG GFVGLAIIFF
     FFAILTVAIL LIMEGLSAFL HALRLHWVEF QNKFYSGQGF KFHPFAFDSI LDGKSED
//