ID A0A3Q1HFW7_ANATE Unreviewed; 362 AA.
AC A0A3Q1HFW7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Shisa family member 9b {ECO:0000313|Ensembl:ENSATEP00000006254.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000006254.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000006254.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Regulator of short-term neuronal synaptic plasticity in the
CC dentate gyrus. Associates with AMPA receptors (ionotropic glutamate
CC receptors) in synaptic spines and promotes AMPA receptor
CC desensitization at excitatory synapses.
CC {ECO:0000256|ARBA:ARBA00037492}.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendritic spine membrane
CC {ECO:0000256|ARBA:ARBA00029429}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00029429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the shisa family. SHISA9 subfamily.
CC {ECO:0000256|ARBA:ARBA00038448}.
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DR AlphaFoldDB; A0A3Q1HFW7; -.
DR Ensembl; ENSATET00000006357.2; ENSATEP00000006254.2; ENSATEG00000004416.2.
DR GeneTree; ENSGT00940000163663; -.
DR OrthoDB; 5350575at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0032591; C:dendritic spine membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31774:SF1; PROTEIN SHISA-9; 1.
DR PANTHER; PTHR31774; PROTEIN SHISA-9-RELATED; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..362
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030079452"
FT TRANSMEM 134..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 257..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 40426 MW; 45353C748471879F CRC64;
MRGTELLLAY FLLKVMVCNA EGELGQTVDD FIIATGFNDS KEGESGVTES PHLEDKCRGY
YDVMGQWDPP FVCRTGNYLY CCGTCGFRFC CAFKSSRLDQ TTCKNYDTPP WMMTGRPPPK
VDVALDAAKD KTNLIVYVIC GVVAIMALIG IFTKLGLEKT HRPNRDNMSR SVGTSPVFVY
HPHQAATRYG NQMNNVVQTS TLITQPYLAV GQITSPYEQQ NPVKDLNKYA TLKAVAEKAN
DSFYSNRRQV IEMTTKGSLP MEAVDMEPEP SNPYSPPRQL SAKQNGHKYK SPKSHSSQSL
SYNANIAASP GVLRSWESRD TLGLRQSHGP KKLCIIEKEL HTTRYIPPQP YYVTNSKTEV
TV
//
