ID A0A3Q1HIJ0_ANATE Unreviewed; 891 AA.
AC A0A3Q1HIJ0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Metabotropic glutamate receptor 3 {ECO:0000256|ARBA:ARBA00020281};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000007250.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000007250.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: G-protein coupled receptor for glutamate. Ligand binding
CC causes a conformation change that triggers signaling via guanine
CC nucleotide-binding proteins (G proteins) and modulates the activity of
CC down-stream effectors. Signaling inhibits adenylate cyclase activity.
CC {ECO:0000256|ARBA:ARBA00025645}.
CC -!- SUBUNIT: Interacts with TAMALIN. {ECO:0000256|ARBA:ARBA00011150}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3Q1HIJ0; -.
DR Ensembl; ENSATET00000007373.2; ENSATEP00000007250.2; ENSATEG00000024646.2.
DR GeneTree; ENSGT01030000234595; -.
DR InParanoid; A0A3Q1HIJ0; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001234; GPCR_3_mGluR3.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF143; GLUTAMATE RECEPTOR, METABOTROPIC 2B; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01053; MTABOTROPC3R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 581..605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 695..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..762
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..796
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 582..848
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 891 AA; 99436 MW; D7C62765D95766AF CRC64;
MLSAVLRSRL ASFAIYWPVR VLLLELLIPG VLPSISRLPP TAKREIIMEG DLVIGGLFPV
HEKGDGTEDC GKINEQRGIQ RLEAMLLALD EINSSDRILP GLQLGAHILD TCSKDTYALE
QSLDFVRASL TKVHDPGFIC PDGSRPIQKE VPLAISGVIG GSYSDVSIQV ANLLRLFQIP
QISYASTSAK LSDKTRYDYF ARTVPADFYQ AKAMAEILRY FNWTYVSTVA SEGDYGETGI
DAFQQEARTR QICIATSAKV SRSMNRQGYE NVIRSLQQKS NAKVVILFTR SEDARQLLVA
AARMNVSFTW VASDGWGAQE SVVRGSETAA DGAFTIELAS YPIREFEDYF TKLNPYTNTR
NPWFKEFWEH RFDCNLQDHG CSEHSLRDGT FEQESKIMFV VNAVYAMAYA LHNMRQAVCS
NTSKVCDAMK PGNGKRFYKE FILKTKFEAP FRPADTENVV RFDSVGDSIS RYNIFHYHKE
EGKFVYKKVG YWEQNLTLNT TLVPWHGHIP PTSQCSDPCR KNEVKSMQPG DVCCWICIPC
QPYQYLQDEF TCADCSFGQW PLANLTGCYD LPEEYIRWED AWAIGPVTIS CLGIMCTLSV
VGLFFKHNET PVVKASGREL SYILLLGVLM CYSMTFIYIA KPSTAVCTLR RLGLGTSFAV
CYSALLTKTN RIARIFSGVK NGAQRPRFIS PASQVAICGA LISCQLLVAV IWLLVEVPGV
RKEVTPERRN VVTLKCNSRE SSMLISLTYN CILIILCTVY AFKTRKCPEN FNEAKFIGFT
MYTTCIIWLA FLPIFYVTAS DYRVQTTTMC VSVSLSGSVV LGCLFSPKIH IILFQPQKNV
ATLRVTANRF SATVSGTASA PSSSYSKGSA SNYVPAVCNG REVVDSTTSS L
//
