ID A0A3Q1HL81_ANATE Unreviewed; 748 AA.
AC A0A3Q1HL81;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
DE EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775, ECO:0000256|PIRNR:PIRNR001251};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000008270.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000008270.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC Evidence={ECO:0000256|PIRNR:PIRNR001251};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|PIRNR:PIRNR001251};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676,
CC ECO:0000256|PIRNR:PIRNR001251}.
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DR AlphaFoldDB; A0A3Q1HL81; -.
DR Ensembl; ENSATET00000008418.2; ENSATEP00000008270.2; ENSATEG00000005747.2.
DR GeneTree; ENSGT00950000183011; -.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd01319; AMPD; 1.
DR Gene3D; 4.10.800.20; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR006650; A/AMP_deam_AS.
DR InterPro; IPR006329; AMPD.
DR InterPro; IPR032466; Metal_Hydrolase.
DR NCBIfam; TIGR01429; AMP_deaminase; 1.
DR PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR PANTHER; PTHR11359:SF3; AMP DEAMINASE 2; 1.
DR Pfam; PF19326; AMP_deaminase; 1.
DR PIRSF; PIRSF001251; AMP_deaminase_met; 2.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR PROSITE; PS00485; A_DEAMINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR001251};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR001251};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040}.
FT REGION 158..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 87302 MW; 07DD286D3007A6E7 CRC64;
CRSLPGTPVS LTHYPIDLRT SMEEKYKEIA EELFTRSMAE SEMRSAPYEF PEDSPIEQLE
ERRHRLERQI SQDIKLMKET SEDTVDDGFK EREMPMERES FYLFIYAAKC VVKALFIREK
YINRSMQSFC KTTAHALQDL GMKPLDLRVY EDIPETPVDA DAPVHPPVSE THPYDNQDPK
NMPADTGYGC KMVDGVVHVY TNKNNMDKST ELDLPYPDLK EYIADMNVMM ALIINGPVKS
FCYRRLQYLS SKFQMHILLN EMKELAAQKK VPHRDFYNIR KVDTHIHASS CMNQKHLLRF
IKRAMKKYPE EIVHIENGQG QTLKDVFESM NLTAFDLSVD TLDMHADRNT FHRFDKFNAK
YNPIGESILR EIFIKTDNYV EGKYFAHIVK EVMFDLEESK YQNSELRLSI YGRSRDEWDK
LAQWAVKHLV YSDNVRWLVQ VPRLFDVYHT KKQLANFQEM LENIFMPLYE VTINPRSHPE
LHLFLEHVVG FDSVDDESKP EHHIFNLDSP LPANWTEEDN PPYSYYLYYT YANMTVLNHL
RRRRGFHTFV LRPHCGEAGP IHHLVSGFML SENISHGLLL RKAPVLQYLY YLAQIGIAMS
PLSNNSLFLS YHRNPLPEYL SRGLMVSLST DDPLQFHFTK EPLMEEYSIA TQVWKLSSCD
MCELARNSVL MSGFSHKAKS YWLGPSYSKE GPESNDIRRT NVPDIRVAYR SETLSEELNL
ITHAVRTEEL DTIYEEDSLS MGPLPGSH
//
