ID A0A3Q1HM16_9TELE Unreviewed; 1266 AA.
AC A0A3Q1HM16;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000029185.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000029185.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR AlphaFoldDB; A0A3Q1HM16; -.
DR Ensembl; ENSAPOT00000020050.1; ENSAPOP00000029185.1; ENSAPOG00000014890.1.
DR GeneTree; ENSGT00940000157842; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR24416:SF614; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1266
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018651497"
FT TRANSMEM 940..964
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..505
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 1032..1266
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 1064
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1266 AA; 141366 MW; A8676F4E33F17D8A CRC64;
MVTLSALLTV YLWIQTQTAS GQQKCPPSPP WLVDFTMTYS LPYFQTDKPI QNIEVNSQVQ
PTELYVACQN VIIAVNDSLQ KTWELKTGPV GHPECETCQV CDIETDPKDP VNTDSQVLFL
DPDQHYLPYL YFCGSTRHGI CYIINIDEPK PETKCLYKKE RNSPTYCPDC LASPLGTKVT
FVQEGATSLF FTAASVNESL RQKYPRRSIS VMRPLSTEDG FDVIMDVTVL PGLRDSYSID
YIYSFSTKDH VYFLSLQREN PFNSNSTFQT RLGRLPILIP EMWMYREVVL ECRYEPKRRR
RREAYRDIVY NGLQAAYFGR AGKDLADELR VHETEDILYG VFAEVNERGQ PQKNSALCAF
PLTKVNHAID RGVEACCKSG PEQLSRGLCH FQPCESCPHE SNDGNDACTA KATLVSQPYY
RVDLFNSQMR NVLFTSVLVT TTGNHTLGHF GTSDGRILQV ILTLYKPIIF ANYSVGETAV
SRTAAVYSKD LLLFVAGNKM FRVPSAGPGC SHFMTCSMCL TAPRFMNCCW CSGSCLRENE
CTSEWNKDSC APVITEFFPK TIPAGGETEL TLCGSEFQSP LRPAIISGKT HIITVGSAMC
SVLSEKSSND ELVCKIHEKN PNLNLNITLQ VHEGEVEGRY SIEGTAQTSG LSFVEPTITE
IKPGYGPMFG ETAVTLTGKY LNSGKQRDVY FGEKKCKIQT VSEETGDLSS IICYTAAAAA
VGPVPVKVII DNFEVTATKM FLYKKDPVIH SVRPQCGFQR GSKLLIEGQN LDSAYKTVVQ
YTSQNPVVTL QQVCNGTTNT THMECWTPAF PEEMAEEKSV PGVISIHTDG KNNLFKRRFD
YHPDAKVIPF ENDDKVLLLK PGDTEVSLHH SKLITVSSCM KITMTIGGVP CKAQVLLNEL
TCRIPKSLVI PSEGLPVKVS VNREVYDVGT VVYDDSSNTV IAGIVLGIVA ALVVGAGLAL
LVMIHLRKKK RVDLSSQTSG SGMAFQGLLY TASYDHLAVP LMARDNISMV SLSSDLLEEV
KDVLIPAEML RIEDSQIIGK GHFGTVYHGY LIDSNKQETH CAVKSLNRIT DLGEVDQFLR
EGIIMKAFHH SNILSLLGIM LPKEGLPLVV LPYMKHGDVR HFIRSEKRNP TVKDLIGFGL
QVAKGMEYLA QKKFVHRDLA ARNCMLDETY TVKVADFGMA RDIYDKEYYS IQDHKRVKLP
VKWMAIESLQ TQKFTTKSDV WSYGILLWEL LTRGASPYPD VDPYDITHYL LKGRRLPQPQ
FCPDTL
//
