ID A0A3Q1HNH8_ANATE Unreviewed; 378 AA.
AC A0A3Q1HNH8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Growth differentiation factor 3 {ECO:0000313|Ensembl:ENSATEP00000006658.1};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000006658.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000006658.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3Q1HNH8; -.
DR STRING; 64144.ENSATEP00000006658; -.
DR Ensembl; ENSATET00000006771.2; ENSATEP00000006658.1; ENSATEG00000004688.2.
DR GeneTree; ENSGT00940000164416; -.
DR InParanoid; A0A3Q1HNH8; -.
DR OMA; AGHCPEW; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13764; TGF_beta_GDF1_3_like; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF151; EMBRYONIC GROWTH_DIFFERENTIATION FACTOR 1; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..378
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018725498"
FT DOMAIN 261..378
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 378 AA; 42532 MW; DFBFCD9EBC269FB4 CRC64;
MSPLVLLAAC FLGVCAVSHV EELKSQERLF LSSLGLSARP RPRPAGGHQP RRRVPSALWR
MFRRSERIQA QESETCVVSE YGVRGNIIRY VQDQGRLGSD WSSSCRGCLE KQLFFNMSVL
QPVELLSLAQ LEIKFHWKPF RSAELLQWSQ PLSVSLHKVI RPTLRGANPQ ANRRLLVSQS
VQLQPESTSI TVDLTSLAEN WRKPGRNYGL VLELLPLPTD PEELLSFHPG NSLPLESALS
LPLFQASLVA VSLNPHQCRS RQKRSAIHLP VTPSNVCKAR SLYIDFKDVG WQDWIIAPQG
YMANYCHGEC PFPLSESLNG TNHAILQTLV HSLDPHGTPQ PCCVPIRLSP ISMLYYDNND
NVVLRHYQDM VVDECGCR
//
