ID A0A3Q1HNT1_ANATE Unreviewed; 511 AA.
AC A0A3Q1HNT1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Early growth response protein {ECO:0000256|RuleBase:RU363046};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000009270.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000009270.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcriptional regulator. Recognizes and binds to the DNA
CC sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target
CC genes. Binds double-stranded target DNA, irrespective of the cytosine
CC methylation status. Regulates the transcription of numerous target
CC genes, and thereby plays an important role in regulating the response
CC to growth factors, DNA damage, and ischemia. Plays a role in the
CC regulation of cell survival, proliferation and cell death.
CC {ECO:0000256|RuleBase:RU363046}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU363046}.
CC -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein family.
CC {ECO:0000256|ARBA:ARBA00005682, ECO:0000256|RuleBase:RU363046}.
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DR AlphaFoldDB; A0A3Q1HNT1; -.
DR STRING; 64144.ENSATEP00000009270; -.
DR Ensembl; ENSATET00000009430.2; ENSATEP00000009270.1; ENSATEG00000006524.2.
DR GeneTree; ENSGT00940000165075; -.
DR InParanoid; A0A3Q1HNT1; -.
DR OMA; NFQVPMI; -.
DR OrthoDB; 2912670at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IEA:Ensembl.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IEA:Ensembl.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR InterPro; IPR021839; EGR1_C.
DR InterPro; IPR021849; EGR_N.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23235:SF42; EARLY GROWTH RESPONSE PROTEIN 1; 1.
DR PANTHER; PTHR23235; KRUEPPEL-LIKE TRANSCRIPTION FACTOR; 1.
DR Pfam; PF11914; DUF3432; 1.
DR Pfam; PF11928; DUF3446; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU363046};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU363046};
KW Metal-binding {ECO:0000256|RuleBase:RU363046};
KW Nucleus {ECO:0000256|RuleBase:RU363046};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|RuleBase:RU363046};
KW Transcription regulation {ECO:0000256|RuleBase:RU363046};
KW Zinc {ECO:0000256|RuleBase:RU363046};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042,
KW ECO:0000256|RuleBase:RU363046}.
FT DOMAIN 313..342
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 343..370
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 371..398
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 132..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 132..207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 511 AA; 54959 MW; 7476E9461DEE0F42 CRC64;
MAAAKTEMIL PTLQISEPLS FPHSPMDNYP KLEEVMMLNP AGTPFLTASA PEGAGFGSGE
PGEQYDHLAG DTLPDIPFNC EKPVSEQTYS TQRLPPISYT GRFTLEPATT CSNSLWAEPI
LGLFTNIMGS VAPSSSSSSG AAQTTSSSSS SASSSSTSSS STSSSQSSSL SSSIHHSEPN
PIYSAAPTYS SPNSDIFPDQ GQAFPTSAGA VQYPPPAYPN GKSCSTSFPV PMIPDYLFPQ
QQGEISLVPP DQKPFQSQSS QPSLTPLSTI KAFATQTGSQ DLKSVYQSQL IKPSRMRKYP
TRPSKTPPHE RPYACPVETC DRRFSRSDEL TRHIRIHTGQ KPFQCRICMR NFSRSDHLTT
HIRTHTGEKP FACEICGRKF ARSDERKRHT KIHLRQKDKK AEKAGAVVVT AAPVSTASPA
SSYPSPITSY PSPVSSYPSP VTSCYSSPVH TSYPSPSVAT TYPSVSMSST FQSQVASSFP
SSVGSNIYSS PVPTPLSDMQ TTLSPRTIEI C
//
