ID   A0A3Q1HNX3_ANATE        Unreviewed;       381 AA.
AC   A0A3Q1HNX3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Ras-related GTP-binding protein {ECO:0000256|RuleBase:RU367014};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000009315.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000009315.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Guanine nucleotide-binding protein that plays a crucial role
CC       in the cellular response to amino acid availability through regulation
CC       of the mTORC1 signaling cascade. {ECO:0000256|RuleBase:RU367014}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367014}.
CC       Lysosome {ECO:0000256|RuleBase:RU367014}.
CC   -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC       {ECO:0000256|ARBA:ARBA00007756, ECO:0000256|RuleBase:RU367014}.
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DR   AlphaFoldDB; A0A3Q1HNX3; -.
DR   STRING; 64144.ENSATEP00000009315; -.
DR   Ensembl; ENSATET00000009475.2; ENSATEP00000009315.2; ENSATEG00000029155.1.
DR   GeneTree; ENSGT00950000183031; -.
DR   InParanoid; A0A3Q1HNX3; -.
DR   OMA; ICNHQAS; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:UniProtKB-UniRule.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IEA:UniProtKB-UniRule.
DR   CDD; cd11385; RagC_like; 1.
DR   Gene3D; 3.30.450.190; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR006762; Gtr1_RagA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039400; RagC/D.
DR   PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR   PANTHER; PTHR11259:SF6; RAS-RELATED GTP-BINDING PROTEIN C; 1.
DR   Pfam; PF04670; Gtr1_RagA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU367014};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU367014};
KW   Lysosome {ECO:0000256|RuleBase:RU367014};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU367014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040}.
SQ   SEQUENCE   381 AA;  43074 MW;  9D28DFC3CAFF864E CRC64;
     MSIQYEVEQL ADSYGVADSF PKDFGYGEEA DIEDSPSPSD SKPRILLMGL RRSGKSSIQK
     VVFHKMSPNE TLFLESTNKI YKDDISSSSF VNFQIWDFPG QVDFFDPTFD YEMIFRGTGA
     LIFVIDAQDD YMEALGRLHL TVSRAYRVNP EINFEVFIHK VDGLSDDHKI ETQRDIHQRA
     NDDLADASLE KLHLSFYLTS IYDHSIFEAF SKVVQKLIPQ LPTLENLLNI FISNSGIEKA
     FLFDVVSKIY IATDSSPVDM QSYELCCDMI DVVIDVSCIY GLREDGSGSA YDKESMAIIK
     LNNTTVLYLK EVTKFLALVC ILREESFERK GLIDYNFHCF RKAIHEVFEV GVSTQRPLGP
     PTVGSPCNKA VALNGTPRNT V
//