ID   A0A3Q1HQ66_ANATE        Unreviewed;      1294 AA.
AC   A0A3Q1HQ66;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=DENN/MADD domain containing 5A {ECO:0000313|Ensembl:ENSATEP00000009544.1};
GN   Name=DENND5A {ECO:0000313|Ensembl:ENSATEP00000009544.1};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000009544.1, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000009544.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the RAB6IP1 family.
CC       {ECO:0000256|ARBA:ARBA00006664}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR   Ensembl; ENSATET00000009714.2; ENSATEP00000009544.1; ENSATEG00000006618.2.
DR   GeneTree; ENSGT00940000153678; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   CDD; cd01757; PLAT_RAB6IP1; 1.
DR   CDD; cd17690; RUN1_DENND5A; 1.
DR   Gene3D; 1.20.58.900; -; 3.
DR   Gene3D; 3.30.450.200; -; 1.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR047278; DEN5A/B.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR047277; PLAT_RAB6IP1.
DR   InterPro; IPR047294; RUN1_DENND5A.
DR   InterPro; IPR004012; Run_dom.
DR   InterPro; IPR037213; Run_dom_sf.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   InterPro; IPR005113; uDENN_dom.
DR   PANTHER; PTHR46070:SF2; DENN DOMAIN-CONTAINING PROTEIN 5A; 1.
DR   PANTHER; PTHR46070; PINSTRIPE, ISOFORM A; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   Pfam; PF02759; RUN; 2.
DR   Pfam; PF03456; uDENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   SMART; SM00593; RUN; 2.
DR   SMART; SM00800; uDENN; 1.
DR   SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR   SUPFAM; SSF140741; RUN domain-like; 2.
DR   PROSITE; PS50211; DENN; 1.
DR   PROSITE; PS50095; PLAT; 1.
DR   PROSITE; PS50826; RUN; 2.
PE   3: Inferred from homology;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          54..603
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   DOMAIN          792..957
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   DOMAIN          961..1069
FT                   /note="PLAT"
FT                   /evidence="ECO:0000259|PROSITE:PS50095"
FT   DOMAIN          1141..1289
FT                   /note="RUN"
FT                   /evidence="ECO:0000259|PROSITE:PS50826"
FT   REGION          686..710
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1294 AA;  148162 MW;  BEA3FA566AB7DC25 CRC64;
     MTTGFSSGSC RFADYFVICG LDTESGLEPD ELSALCQYIE ATKFRDGARG KCAGANEGEN
     FEQSPLRRTF KSKVLAHYPD NVEWNLFDQD AVGMLCMPKG LSFRTQVDSR EPQFHSFIIT
     REDGSRTYGF ALTFFEEVTS KQICSAMQTL YHMHNAEQYD ILHTPTSPQA STADQRHQHL
     QSRPVLHSAP AISRLQRFNS YDISRDTLYV SKCICLITPM AFPQACRKVL QQLHQAVTSP
     QPPPLPLESY IYNILYEVPL PPSGRSLKFS GVYGPVVCQR PSTCELPLFD FAISEMFNLL
     GVENVLQLFT CALLEMQILL YSQHYQRLMT VAESITALMF PFQWQHVYVP ILPASLLHFL
     DAPVPYLMGL HSNGQDDRTK LELPQEANLC FVDIDNHFIE LPEDLPQFPN KLEFIQEISE
     VLMSFGVSPE GNIPSSDSQA KYRVFRSVDM VSDKRNGNLA SPLTSYLLRE NETIARLQAL
     VKRTGVSLEK LEVREDASSN KDLRFQCDEE ELKMHQINIQ VREVFANRFT QMFADYEVFV
     IQPSQDKESW FTNRDQMQNF DKASFLSDQP EPYLPFLSRF LETQMFASFI DSKILCHDDE
     EKEHTLRVFD SRVDKIRMLN VRTPTLRTSM YQKCTNIEEA EKAIEMRVSK IDHTALHPHL
     LDMKIGQGRY EQGFFPRLQS DVLSTGPTSN KWTKRSAPAQ WRRRDRQKQH AEHLYLDNDQ
     REKYIQEARN LGTTIRQPKL SNLSPSVIAQ TNWKFVEGLL KECRNKTKRM LVEKMGREAV
     ELGHGEVSIT GVEENTLIAS LCDLLERIWS HGLQVKQGKS ALWSHLLHYQ ESKEKNNATP
     GGLGPPGFIH DTERRKSDGG GSAMPPLKVS LIQDMRHIQN ISEIKTDVGK ARAWVRLSME
     KKLLSRHLKQ LLSEDELTKK LYKRYAFLRC DDEKEQFLYH LLSFNAVDYF CFTNVFTTIM
     IPYHVVVVPS KKLGGSMFTA NPWVCVSGEL AETGVLQVPR NTLEITFECQ NLGKLTTVQI
     GHDNTGLYAK WLVECVMVRN EITGHTYKFP CGRWLGKGVD DGSLERILVG ELITPSTEND
     ERMCRTPPMQ QSPGMMRRFV TISPNSKPKL NTGQIQEGVG EAINGIVKHF HKPEKERGSL
     TLLLCGEYGL VWALEQVFQH GFKSPRLFKN VFIWDFLEKA QVYFESAEQR EVTPDENWQT
     RVRHFCRFMR AINNTSRNIG KDGKFQMLVC LGARDHLLHH WIALLADCPI TAQMYEDTAL
     IKDRSLVNSL IRVLQTLQEF NITLEASLVK GVGI
//