ID A0A3Q1HR16_9TELE Unreviewed; 538 AA.
AC A0A3Q1HR16;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Merlin-like {ECO:0000313|Ensembl:ENSAPOP00000030330.1};
OS Acanthochromis polyacanthus (spiny chromis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Acanthochromis.
OX NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000030330.1, ECO:0000313|Proteomes:UP000257200};
RN [1] {ECO:0000313|Ensembl:ENSAPOP00000030330.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR AlphaFoldDB; A0A3Q1HR16; -.
DR Ensembl; ENSAPOT00000022295.1; ENSAPOP00000030330.1; ENSAPOG00000016853.1.
DR GeneTree; ENSGT01020000230354; -.
DR Proteomes; UP000257200; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.5.450; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.10.360.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR011174; ERM.
DR InterPro; IPR011259; ERM_C_dom.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR008954; Moesin_tail_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR23281:SF23; MERLIN; 1.
DR PANTHER; PTHR23281; MERLIN/MOESIN/EZRIN/RADIXIN; 1.
DR Pfam; PF00769; ERM_C; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF48678; Moesin tail domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000257200}.
FT DOMAIN 1..271
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 397..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 278..326
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 397..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 538 AA; 62559 MW; 395CFFA7C375B7C9 CRC64;
MTCPAVEKKK MKSALGHRHV YTVCVKTEEG ELEFLYRLRS QGVPLKEPIT FRLMIKFYPE
NVEQELLEDI TQHLFFLQLK RMILEEEIYC PPDVSVLLAS YAVHAEYGDY DPDVQKPGFL
AVTSLLPKRF INLYIMTTAM WEEKITACYA QHRGKSREEA EMEYLKIAQD LDMYGVDYFL
IRNMKGHDLL LGLHALGLHI YKPGNKLTPE VTFIWSEIHR MSFEWNMFLI KVLGKKSNLV
KFKSSEGKGC KITSMILSLC MGNHELFMRR RNPDSMEMQE IKIQVAMQRS RKEEAKQRLQ
KERQLREAAE RARDEMEMSL IQLQNDVHMS NVLLLCLGQD LLAEKAKTTE HNAKPLAQKA
IKAETEKQHN EVPAICGQED PEKMLEAEMV ALKMDEESEK WDMEDEQLKQ ELQEASDAER
EEKHNLLEIT SKSPGLPSDS VPRELSFSRE DLCFDFKDTD MKSFFTVTEK KKVAKKKNLH
EVLKEMKTEM ELLRLKGHET PLDCIYFQNK ALGITKHSTL MMLTLQSSES KLAHYETL
//
