ID A0A3Q1HSH2_ANATE Unreviewed; 2776 AA.
AC A0A3Q1HSH2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Rho guanine nucleotide exchange factor 17 {ECO:0000313|Ensembl:ENSATEP00000011882.1};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000011882.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000011882.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 64144.ENSATEP00000011882; -.
DR Ensembl; ENSATET00000012076.2; ENSATEP00000011882.1; ENSATEG00000008285.2.
DR GeneTree; ENSGT00940000153798; -.
DR InParanoid; A0A3Q1HSH2; -.
DR OMA; CKSHRIY; -.
DR OrthoDB; 2917131at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265040}.
FT DOMAIN 1794..1982
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 22..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 971..1017
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1462..1689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1740..1788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2289..2426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2699..2733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..78
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 971..986
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1462..1484
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1486..1528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1578
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1756..1786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2298..2323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2345..2388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2702..2720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2776 AA; 302821 MW; 36C50C83F213DFB8 CRC64;
MADRGSRNAA VYRSVSFKKL GSCTAGRSED QQRKPLDLEA AGVALPPEHN KAEQPSATRN
VSVSRKVSKI SAATTATAAG LPTADPKRGS STPLCSISPS IRQLTEKFSS STSSSSSSVS
SSGGSTRTHR ASPGDGAAVT RGSCTLPRAG GSRRDGSLNR KSFHEDSGGG CYQDSDSASL
TTEALTDSKV RKVHSGTDSV SGSDTEKRNE KRIFTRLSAD NSSSSSSSSG KRDHLQITAC
ASDPRKTLAT DEEEDVTSRC FSPTCKSHRI YLSTHHSDFI PLHSEKWPSV TKIRQLFDER
QSKAAHHKTD TEDLKTGSRG HLHELGPAES APLSDTDDKL SPHNCANEAR SLSLHDRCVV
GAQSRESSTA KETFCFGMDF NSRADHQQYS NDEEADIETQ SSNNNNVSGR DTLQSRSSSS
SCSHTVGSHY CRINPSPYRS HSPSTEAEAA RKNPKTTSDL NPDLQRSATW SWSRSVSLDN
SLCSSSLQQP AVRERRDRQG VGLPRDSLHS SHSSSKAPAP TAFSLFSAVA PDKAITSSSS
STVAPSTEFR APSRVASPLS SRWRFSSGDE EEEHTRRRRV GGWSIPSDTA PSFSYRGGER
GTIERGGSCL PRSKNGWWAA KGIGRSSGSE EDSPGTLGPH SREAVRRRSL RKKKKVSGLA
LATGRDDYDD HDGESEDSDS DTALTMEHLE RQSQQKSGEF VATVSRSHLA REPSSHNNTG
RVQQWERISS PVTPATLSGV SRVSKVNIPQ FVSSPGGSRC SSRYSSTETL KEEDQVSCAN
RAGNVFFNSG GVGVGTSRTA SSSMLSKTYH GNFTMYRSPS FGHGDNFSRA PVRVRPKIVP
TVAHLPSVHT REGVSAGVRS GETKTLKRTT GEEGVDADKN RISMSNPDIT SETMTLLSFL
KSDLSELKVR KASGGDNSGV VEGSSMYKLG SRTHGGTLLH SGRRPSLKDL TATLRRAKSF
TYSEKPTTPV RCYMTGGTTM RSSSEQQLDL DGERHGGRVP VSDREVESDG GDFRAGRGQR
MRDYAFDDDG DEELMPTPLQ ERYVQEAQQV IRDICQMNTR EDDIDNADDV AAKKISDNLD
DKCLQIKNLN EKKENTGMSV MDETIKDQEA EFKNTKDGDK HKRGRENRER ERERDGQSMQ
LEKLNSRGTE YREKATRPNR ETDRALLKGN SEESMLYDRS VDELSSHESS LTDEGIVTEP
ETGPSDPSEM SFLGSTGVNL GTRITRDVLG QPVTVWKQSA LHEAEGFKQE REEMAESSMS
CANRLNEVTG PFSLLHSAHM AESDRIIMDL RTTAGANNLT STNEEISITS AVAQGSAATA
GGGLESPATP SAIRRRRKFS PSGNNNTGSD SSNGSNAEST TAAGNGESTV YRSLSDPMPQ
RRCSVAEEGN NFSSVDSNLL GSLSVKGGGG APEVSAVATL SEYKGSVASD LSVYSDGGLR
DDSVRDYSGM IRSIVAEPGA MDRLITDDHG NGKAPKKKSF SDPSRRSDAP LLSQNDPHFK
GQSSGTQPIG ELDQPGQIPP SSSEPILSEQ REELWEPEVK PKHTLPTQPD HHANDSDKVK
KARSQSECTP HSENHDDEDD DVIDHGGDAK EEEERRFDFD LRLAEVLSPR MVRRPSRKRP
NRLAHFFPHE DSFEPPELGS EGQEVQGDQT DLTPPLPPPP LQSKPKARPK HVRHASEPAT
FIPISPPPQL QPLKEADCVS LGCTVESPIL TKSPGDETPS LEDVTQKYIL ELSTTERDVK
GTGPLLVPKD GAEGSGGSAE TSTSGITEAA PQKKSIEDTT SMPVPQRTKP RVDMRKHVMM
TLLDTEQSYV ESLRTLIQAY MRPLKHPDSG SIVDPLLVDE MFYQIPEILE HHEHFLEQVS
GCVGQWHDRQ TIGHLLIQSF SRETLANMYS AYIDNFLNAK DAVRVAKEAK PAFHKFLEQN
MRENKEKQAL GDLMIKPVQR IPRYELLVKD LLKHTPEDHP DHPLLLDAQR GIKRLAEKIN
KGRHSAEEAE REARVIQEIE AHIEGVEHIL NPQRKFLRQE MVMEAKTVGG KKDRSLFLFS
DLMICTTLKR KSGSLRRSSM SLYSAASVID TSSKYKFLWK LPLEDVEVVK SPTQATNKES
IQKMISRLDE DLSTLGQISK LSETLSFPHQ SLDEVIKDLM ASVHRELSDK QSLAFSMTFL
PTKLEFTTAS AESSFVFEFT TPDARSNFEQ AFEEAKKKLA MNKDQWDPEF LKAIPIMKTR
SGMQFSCASP SHSCPDSGCE VWVCNSDGYV GQVCLLNIRD EPTVEACIAV CSARIICIAA
VPGLKGRERG AELSHTPNSG APGHTQQQLH ISISHSSLEL TEQPTGPGAE LVPFDSDDTD
DEDSPSPSST LQSQASHSTI SSSYGNDEGP GSKDMATETT SSEEEQEFPP ASSYGAPGML
GVGGGSRAQA ESPMDGRAMR RSSRGSFTRA SLEDLLSIDP EAYQSSVWLG TEDGCIHVYQ
SSDNIRNRKN SMKMQHSASI LCILYLDNKV FVSLANGEVI VYQREAGSFW DPQSSQTLVL
GTPSSPITKM VPVGGKLWCG SQNRVLIINT TTLVQEHWFQ VGTDSSRCVT CMVAYGQGVW
LALQGSAQVK LYHAQTWESL TEVDVAPAVH KMLAGADAII RQHKAACLRI TALLACKDLL
WIGTSAGVVL TLAIPAVSSG TGAGTLKSPL VPMGSAHGHT GHVRFLTTIE LPEGFDMNLP
PPTADSTGNQ SQSCSAVDRS LQRRDSARRR ASAHIPSKTN YLVISGGDGY EDFRLTNSSE
TVGRDDSTNH LLLWRV
//
