ID A0A3Q1HVV4_ANATE Unreviewed; 806 AA.
AC A0A3Q1HVV4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Rho GTPase-activating protein 12-like {ECO:0000313|Ensembl:ENSATEP00000013132.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000013132.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000013132.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1HVV4; -.
DR Ensembl; ENSATET00000013348.2; ENSATEP00000013132.2; ENSATEG00000009114.2.
DR GeneTree; ENSGT00950000182860; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12070; SH3_ARHGAP12; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035491; ARHGAP12_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF107; RHO GTPASE-ACTIVATING PROTEIN 12; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF16618; SH3-WW_linker; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 8..70
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 268..295
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 360..387
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 429..535
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 615..804
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 79..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..95
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 91824 MW; 959FF1813AE62E56 CRC64;
MAELPIAPGQ VYIEVEYDYD YKSKDRLVSI RQGECYMLVK KTNEDWWQVK KEEGAKPFYV
PAQYVREVRK ALMPPPKPIT QLPAASNPPP PGGAALWVKP TNLDVGTRDR SPENLHGRES
NYRRSPSAQT GHPSPPGQRR DTSNHHTPSS PTDHDRTLAD IVVPLPPQKG KSSTLPRTRP
RSPEMVRAPL DVDSTHHCDS AGEERRTNDS ESGDELSSSS TEHLQTVSSS CQGRSESPVY
TNLQELKITQ TNLPPQPSSS PIYVLGDWET HKDQNGRHFY YNRSTHERTW KPPRAKDTNS
GNSRGESHSV GEPLSSEDTC FSTYSSQSDS QYGSPPRGWS EEMDEYGHTL YVSDYTNEKW
LKHVDDQGRP YYYSADGSRS EWELPKYNLS PPQPCGDATK SHSLDRKHVE PIVLTKWRHS
TYLLDPNDKL QYEQKYFCVS ELCCRKNWTS SWTVLQGTHL LFTKGQGGST SWFSQSKPEI
TVDLRGGSAE WASKDKSSKK HVIEVKTRQG TELLIQSEND TLINDWYRVL QDVISTHAWE
SDEAIEEDMP ESPGGEKHDK EKEHRDSKKG RGTSTSVDAT DHKKTKHKLK KFLSGRPTLQ
SIRDKGYIKD LVFGCSLSSL CQRENSTVPA FVKMCIDHVE NSALCVDGLY RVSGNLAVIQ
KLRYAVNHDE KVNLADGKWE DIHVTTGALK MYFRELPEPL FTYTFFHDFV NAIKTSDYRQ
RVQGIKELVN KLPKPNHDTM QALFKHLRRV IEHGEENRMT TQSVAIVFGP TLLRPETETW
NMAVHMVYQN QIVELILLEY ENIFGR
//