ID   A0A3Q1HZB3_ANATE        Unreviewed;       539 AA.
AC   A0A3Q1HZB3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Protein wntless homolog {ECO:0000313|Ensembl:ENSATEP00000012684.2};
GN   Name=WLS {ECO:0000313|Ensembl:ENSATEP00000012684.2};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000012684.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000012684.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004439}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004439}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004653}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the wntless family.
CC       {ECO:0000256|ARBA:ARBA00008148}.
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DR   AlphaFoldDB; A0A3Q1HZB3; -.
DR   STRING; 64144.ENSATEP00000012684; -.
DR   Ensembl; ENSATET00000012891.2; ENSATEP00000012684.2; ENSATEG00000008864.2.
DR   GeneTree; ENSGT00390000005897; -.
DR   InParanoid; A0A3Q1HZB3; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR047843; WLS-like_TM.
DR   InterPro; IPR009551; Wntless.
DR   PANTHER; PTHR13449; INTEGRAL MEMBRANE PROTEIN GPR177; 1.
DR   PANTHER; PTHR13449:SF2; PROTEIN WNTLESS HOMOLOG; 1.
DR   Pfam; PF06664; MIG-14_Wnt-bd; 1.
PE   3: Inferred from homology;
KW   Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   TRANSMEM        228..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..281
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        301..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        374..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        427..447
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        467..488
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          175..491
FT                   /note="Wntless-like transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF06664"
SQ   SEQUENCE   539 AA;  61896 MW;  E114DD9CE0BB1657 CRC64;
     MAGAIIENMS TKKLVFLGFS VLVFQVISIM VGALIAPSPT SAIRYLATKC INRHRARGWL
     VPWGSKRCQQ VHSFDEPLAK TLDANDIVFS VHVPLPGMEM SPWFQYLLAV LQLDITFKMI
     NQIEDDVILT IDAGLAYRDN LMSEWTTKFH SVEQRPLKCT LAVPKTYENE GRFYHCEPIP
     LMELSSVAHK YFLINLRLPV NDTVNTGIGE IKDIHIVGIH QNGGFTKVWI SMKTVFTPWI
     FVATAWYWYR IRLTGRPPVL LEKLIFALGI SMTFLNVPVE WFSLGLEWTW MLLFEDVRQG
     VFYSALFCFW IIFCGEHLMD QRLRNRLSAY WWQVGLVVFG SSILLIFDLI ERGVHLNNPL
     HSVWASDIGT KVSITFIILA GISMCLYFLS LCHMVRCVFR NIGGKIQRLP AMPEARRLRY
     RGIIFRFRFL MLVTLACAAM TVIFFIINQV SESPWHWGEY NLQVYSAFLT GTYGMWNLYV
     FTIIFLYAPS HKHNRKSNAT EFYLSSLSNL SKEGFFEDAV SRHGQTAELL VQMAGAPVL
//