ID   A0A3Q1HZC6_ANATE        Unreviewed;       857 AA.
AC   A0A3Q1HZC6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Cadherin-2-like {ECO:0000313|Ensembl:ENSATEP00000010358.2};
GN   Name=CDH2 {ECO:0000313|Ensembl:ENSATEP00000010358.2};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000010358.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000010358.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC       {ECO:0000256|RuleBase:RU004357}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC       {ECO:0000256|ARBA:ARBA00004536}. Cell membrane, sarcolemma
CC       {ECO:0000256|ARBA:ARBA00004135}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251,
CC       ECO:0000256|RuleBase:RU003318}. Cell surface
CC       {ECO:0000256|ARBA:ARBA00004241}.
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DR   AlphaFoldDB; A0A3Q1HZC6; -.
DR   STRING; 64144.ENSATEP00000010358; -.
DR   Ensembl; ENSATET00000010540.2; ENSATEP00000010358.2; ENSATEG00000007302.2.
DR   GeneTree; ENSGT00940000155981; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 4.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR039808; Cadherin.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR014868; Cadherin_pro_dom.
DR   InterPro; IPR000233; Cadherin_Y-type_LIR.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   PANTHER; PTHR24027:SF79; CADHERIN-2; 1.
DR   PANTHER; PTHR24027; CADHERIN-23; 1.
DR   Pfam; PF01049; CADH_Y-type_LIR; 1.
DR   Pfam; PF00028; Cadherin; 4.
DR   Pfam; PF08758; Cadherin_pro; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   PRINTS; PR01820; DESMOCOLLIN.
DR   SMART; SM00112; CA; 5.
DR   SMART; SM01055; Cadherin_pro; 1.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 2.
DR   PROSITE; PS50268; CADHERIN_2; 5.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043};
KW   Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW   ECO:0000256|RuleBase:RU003318};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003318};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        667..698
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          112..219
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          220..334
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          352..449
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          450..557
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          556..667
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   857 AA;  95281 MW;  4B7FBABE9F1D3BE8 CRC64;
     LIALKKALLS FVDCSGGKVW FEIGDSPDFR VSEDGVIYAL RRLSMAGKEN AVVVVYAQDL
     QSKKVWKTRV HLHVRPNETE ESINSSPVPE ILFPWRSVVV RGDGTMKRVK RDWVIPPISV
     PENSRGQFPE DLVRIRSDRD KNRMLRYSVT GPGADQPPTG IFIINPISGQ LSVTKPLDRE
     HISNFHLRAH AVDLNGNQVE NPIDIVINVI DQNDNRPEFT HTIFNGSVPE GSKPGSFVMT
     VTAVDKDDPK TANGMLRYKI LSQNPQSPSS NMFTINNKTG DIITVAAGLD REKVTQYTLI
     IQATDMEGNP TYGLSNTATT IIRITDVNDN PPEFTTDTFF GEVHENRVNV IVANLTVTDK
     DQPHTPAWSA VYRIIAGDPT GRFSIPTDPT TNEGLLTVVK PVDFEQTRSF MLTVEAENEV
     ALARGIHLPR QSTATVSVRI LDINESPEFT PNPKLIKLEE GLPAGSMLTS FTAQDPDRFM
     RQIVRYSKMY DPAKWLEIDP VNGRISTIAI LDRESPYVKN NLYNVTFMAY DNGVPPATGT
     GTLQIHLLDI NDNAPHVFPS DVEMCERPDP NAINITASDP DLNPNAGPFV FELANRPSDI
     RRNWTLNRLS GEYAQLRLRI GSLASGIYDI PIMITDSGNL PMSNMSYLRV KVCQCDHHGD
     CVDMERIIAA GLGTGAIIAI LICIIILLVL VLLFVMWMKR RDKERQAKQL LIDPEDDVRD
     NILKYDEEGG GEEDQDYDLS QLQQPDALEP ECVKVGIRRM DERPLHHDHQ YPLRSAAPHP
     GDIGDFIHEG LKAADNDPTA PPYDSLLVFD YEGSGSTAGS LSSLHSSSSC GDQDYDYLGD
     WGPRFRKLAD LYGGGDD
//