ID   A0A3Q1I1D6_9TELE        Unreviewed;       384 AA.
AC   A0A3Q1I1D6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Endoplasmic reticulum-Golgi intermediate compartment protein {ECO:0000256|RuleBase:RU369013};
OS   Acanthochromis polyacanthus (spiny chromis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Acanthochromis.
OX   NCBI_TaxID=80966 {ECO:0000313|Ensembl:ENSAPOP00000033505.1, ECO:0000313|Proteomes:UP000257200};
RN   [1] {ECO:0000313|Ensembl:ENSAPOP00000033505.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Plays a role in transport between endoplasmic reticulum and
CC       Golgi. {ECO:0000256|RuleBase:RU369013}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU369013}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000256|ARBA:ARBA00004457,
CC       ECO:0000256|RuleBase:RU369013}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004457, ECO:0000256|RuleBase:RU369013}. Golgi
CC       apparatus membrane {ECO:0000256|RuleBase:RU369013}; Multi-pass membrane
CC       protein {ECO:0000256|RuleBase:RU369013}. Golgi apparatus, cis-Golgi
CC       network membrane {ECO:0000256|ARBA:ARBA00004257}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004257}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ERGIC family.
CC       {ECO:0000256|ARBA:ARBA00005648, ECO:0000256|RuleBase:RU369013}.
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DR   AlphaFoldDB; A0A3Q1I1D6; -.
DR   Ensembl; ENSAPOT00000028469.1; ENSAPOP00000033505.1; ENSAPOG00000022150.1.
DR   GeneTree; ENSGT00530000063113; -.
DR   Proteomes; UP000257200; Unplaced.
DR   GO; GO:0030134; C:COPII-coated ER to Golgi transport vesicle; IEA:UniProtKB-UniRule.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IEA:UniProtKB-UniRule.
DR   InterPro; IPR045888; Erv.
DR   InterPro; IPR012936; Erv_C.
DR   InterPro; IPR039542; Erv_N.
DR   PANTHER; PTHR10984; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN; 1.
DR   PANTHER; PTHR10984:SF25; ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3; 1.
DR   Pfam; PF07970; COPIIcoated_ERV; 1.
DR   Pfam; PF13850; ERGIC_N; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU369013};
KW   ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW   ECO:0000256|RuleBase:RU369013};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU369013};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369013};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257200};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU369013};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU369013}; Transport {ECO:0000256|RuleBase:RU369013}.
FT   TRANSMEM        24..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369013"
FT   TRANSMEM        342..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU369013"
FT   DOMAIN          7..97
FT                   /note="Endoplasmic reticulum vesicle transporter N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13850"
FT   DOMAIN          146..364
FT                   /note="Endoplasmic reticulum vesicle transporter C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07970"
SQ   SEQUENCE   384 AA;  43273 MW;  E919E61968D5370A CRC64;
     MDTLNKLKQF DAYPKTLEDF RVKTWGGATV TIISGVIMLI LFVSELQYYL TKEVHPELYV
     DTSRGDKLKI NIDVIFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDK DLKPVTLEAE
     KHELGKADDG DVFDPSTLDP NRCESCYGAE TEDLKCCNTC DDVREAYRRR GWAFKSADTI
     EQCKREGFTQ KMQEQKNEGC QVYGFLEVNK VAGNFHFAPG KSFQQSHVHV HDLQSFGLDN
     INMTHLIKHL SFGKDYPGIV NPLDGTDVTA PQASMMYQYF VKIVPTIYMK TDGEVVKTNQ
     FSVTRHEKVA NGLIGDQGLP GVFVLYELSP MMVKFTEKHR SFTHFLTGVC AIIGGVFTVA
     GLIDSLIYHS ARAIQKKIEL GKAS
//