ID   A0A3Q1I3I4_ANATE        Unreviewed;       822 AA.
AC   A0A3Q1I3I4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000014740.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000014740.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; A0A3Q1I3I4; -.
DR   Ensembl; ENSATET00000014974.2; ENSATEP00000014740.2; ENSATEG00000010175.2.
DR   GeneTree; ENSGT00950000182881; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF22; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 2; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        387..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        432..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        524..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        554..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        620..643
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        752..775
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          86..113
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   822 AA;  94545 MW;  9D797548AA59C512 CRC64;
     MCSMLRGEEM CLAQLFLQSG SAYDCISELG ELGLVEFRDL NPSVNAFQRK HVNEIKKCEE
     MERILGKHIW ILSEQFGNED LFIEQLQRLE VELGEVSRNK DKLQKNLLEL KEYTHMLRIT
     RNFVQRTTEY EEFPFLEKDP RMDYSSLQRL GAKLGFISGL IHRVKIEAFE RMLWRVCKGY
     TILSYTEVEE YLDDPDTGEP TKSVVFLISY WGDQIGQKVK KICDCYHCHL YPYPSSNEER
     NDVVEGLRTR IQDLHTVLCR TEDYLKQVLI KASESVYTWV IQVKKMKAIY YILNQCSFDV
     TNKCLIAEVW CPVNDIPTLR RSLEEGSRKS GATVPSFVNR IPTNETPPTL IRTNKFTSGF
     QNIVDAYGVG SYREINPAPF TIITFPFLFA VMFGDLGHGV IMALFALWMV LFENNRKLKN
     TRNEIWNIFF EGRYIILLMG LFSVYTGLIY NDCFSKSLNI FGSGWNVKAM FSAKVATNIS
     ENRFLSLDPN VTGVFKGPYP LGIDPIWNFA NNRLTFLNSY KMKMSVILGI IHMSFGVILS
     AYNHLHFRKK YNLYLVFIPE LLFLLCLFGY LVFMILYKWL SFTAKHSSEA PSILIHFINM
     FLMQGDLKQA LYPGQAGLQI FLVIVAVLSV PVLLLGKPVY LYWLKNGNQR LGMYRGYERV
     RRNSDEELYL LRAHDMEEGS SHSDFSTSGE HETEEVNEFL HQAIHTIEYC LGCISNTASY
     LRLWALSLAH AQLSEVLWTM VMRVGLRVNS GLGVLFLVPV FGLFAILTVS ILLIMEGLSA
     FLHALRLHWV EFQNKFYSGA GVKFSPFSFS LLPSSLLGDG LL
//