ID   A0A3Q1IBE8_ANATE        Unreviewed;       848 AA.
AC   A0A3Q1IBE8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=PMS1 homolog 2, mismatch repair system component {ECO:0000313|Ensembl:ENSATEP00000018902.2};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000018902.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000018902.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   AlphaFoldDB; A0A3Q1IBE8; -.
DR   STRING; 64144.ENSATEP00000018902; -.
DR   Ensembl; ENSATET00000019218.2; ENSATEP00000018902.2; ENSATEG00000013164.2.
DR   GeneTree; ENSGT00940000155381; -.
DR   OrthoDB; 4698638at2759; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040}.
FT   DOMAIN          224..361
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          664..808
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          506..583
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        506..526
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        527..548
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..571
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   848 AA;  94406 MW;  57497E768736B8CB CRC64;
     CQRAAMITTE PAGAIKAIDK HSVHQICSGQ VVLSLATAVK ELVENSIDAG ATNIDVKLKE
     CGAEQVEVSD NGKGVEEANF EGLTLKHHTS KLRDFSDLIH VETFGFRGEA LSSLCALSVV
     TCHESSQVGT KLVFDHKGHL VQRSPHPRQQ GTTVSLQQLF YTLPVRHKEF QRNIKKEYSK
     MVHVLQSYCI ISTGVRITCS NQNGQGKRST VLSTSGSQSM RDNIGAIFGP KQIQSLLPFQ
     QVSPTENIIE EYGLKDADLP KQLFTITGFV SRGDHGVGRS ATDRQFFFIN NRPCDPLKVT
     KLVNEVYHMY NRHQYPFVAL NITVASECVD VNVTPDKRQI FLQEEKLLLA ILKTSLINMY
     EAGVNKINTT SACDLSQVFS SDDSKPGEDV KPVIQSPKSS LNLAGLKAAF SSQRSSNSQS
     KSGLANSGPT QKTLQLFFKG SVKPPTSTAS VKCPLKPTRD LATCPPVGKS VLDGFRYGKM
     CSDTDNEKDS AASSCDLNTS DSYCSGLELS SHEPTVSSPS VENETFEETS DNSHTVPEDS
     ELKPEPSTYT EDETISPNAK RARKENPNFS TKDKPKTFSN SSEEPFSLVV DAPVCLQRRK
     VLLQFSLQEL AEKMRQLHDQ HKERESGKLC YRRFRAKINP GENQSAEEEL KKEISKDMFK
     EMEIIGQFNL GFIITKLSSD IFMIDQHATD EKYNFEMLQQ HTVLQGQKLI VPQKLHLTAI
     SENVLIENIE IFRKNGFEFL INEDAPVMER VKLVSLPTSK NWTFGPADIE ELIFMLSDSP
     GVMCRPSRVR QMFASRACRK SVMIGTALSV NEMKKLVAHM GDIEHPWNCP HGRPTMRHLA
     NLDIISQD
//