ID   A0A3Q1IC22_ANATE        Unreviewed;       322 AA.
AC   A0A3Q1IC22;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Ras-related GTP-binding protein {ECO:0000256|RuleBase:RU367014};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000017084.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000017084.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Guanine nucleotide-binding protein that plays a crucial role
CC       in the cellular response to amino acid availability through regulation
CC       of the mTORC1 signaling cascade. {ECO:0000256|RuleBase:RU367014}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU367014}.
CC       Lysosome {ECO:0000256|RuleBase:RU367014}.
CC   -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC       {ECO:0000256|ARBA:ARBA00007756, ECO:0000256|RuleBase:RU367014}.
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DR   AlphaFoldDB; A0A3Q1IC22; -.
DR   STRING; 64144.ENSATEP00000017084; -.
DR   Ensembl; ENSATET00000017373.2; ENSATEP00000017084.2; ENSATEG00000011885.2.
DR   GeneTree; ENSGT00950000183031; -.
DR   InParanoid; A0A3Q1IC22; -.
DR   OrthoDB; 33171at2759; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:UniProtKB-UniRule.
DR   GO; GO:0032008; P:positive regulation of TOR signaling; IEA:UniProtKB-UniRule.
DR   CDD; cd11384; RagA_like; 1.
DR   Gene3D; 3.30.450.190; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR006762; Gtr1_RagA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039397; RagA/B.
DR   PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR   PANTHER; PTHR11259:SF1; RAS-RELATED GTP-BINDING PROTEIN; 1.
DR   Pfam; PF04670; Gtr1_RagA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU367014};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU367014};
KW   Lysosome {ECO:0000256|RuleBase:RU367014};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU367014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040}.
SQ   SEQUENCE   322 AA;  37484 MW;  875C74CBCD5CCA9B CRC64;
     MSSTAMKKKV LLMGKSGSGK TSMRSIIFAN YIARDTRRLG ATSKNTLNQV DVEHSHVRFL
     GNLVLNLWDC GGQDTFMENY FTSQRDNIFR NVEVLIYVFD VESRELEKDM HYYQSCLEAI
     LQNSPDAKVF CLVHKMDLVQ EDQRDLIFKE REEDLKRLSR PLACTCFRTS IWDETLYKAW
     SSIVYQLIPN VQQLETNLRN FAQIIEADEV LLFERATFLV ISHYQCKEQR DAHRFEKISN
     IIKQFKLSCS KLAASFQSME VRNSNFAAFI DVFTSNTYVM VIMSDPSIPS AATLINIRNA
     RKHFEKLERV DGPKHSLHMR MR
//