ID A0A3Q1ICU8_ANATE Unreviewed; 366 AA.
AC A0A3Q1ICU8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Transcription factor 7 {ECO:0000313|Ensembl:ENSATEP00000017990.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000017990.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000017990.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TCF/LEF family.
CC {ECO:0000256|ARBA:ARBA00006569}.
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DR AlphaFoldDB; A0A3Q1ICU8; -.
DR STRING; 64144.ENSATEP00000017990; -.
DR Ensembl; ENSATET00000018290.2; ENSATEP00000017990.2; ENSATEG00000012486.2.
DR GeneTree; ENSGT00940000159831; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd21996; HMG-box_TCF7-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013558; CTNNB1-bd_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR024940; TCF/LEF.
DR PANTHER; PTHR10373:SF33; TRANSCRIPTION FACTOR 7; 1.
DR PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR Pfam; PF08347; CTNNB1_binding; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 278..346
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 278..346
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 41097 MW; C058ACACEB3916B4 CRC64;
MPQLSSGGGD DLGANDEMIA FKDEGEQEEK IQENAFTERD LADLKSSLVN ESEINQSPNA
AVRRAQQGEQ RVYPDKHREH LDGVSKQQDG GMYKTPGYPG YPFLMLPDAY LPNSSVSSSS
NKVSVVQQSH GMHPLTSLLP YSNEHFSPSP PHLPIDIDMS QKTGVHRHQS QDLSGYYSLS
SGGVGQITPS MSCPPVYPGL SPCGFRQTYS SNLSSASSYS RFPHSLMLGP SGMHPTGIPH
PAIVPPTGKQ EHDQYDRGMY VKPQVEAKRE KEPKKPVIKK PLNAFMLYMK EMRAKVIAEC
TLKESAAINQ ILGRRWHALT REEQAKYYEL ARKERQLHMQ LYPTWSARDN YNKRQTRTDS
TVQNRF
//
