ID A0A3Q1IHF8_ANATE Unreviewed; 645 AA.
AC A0A3Q1IHF8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Nuclear receptor subfamily 1 group D member 1 {ECO:0000256|ARBA:ARBA00039258};
DE AltName: Full=Rev-erbA-alpha {ECO:0000256|ARBA:ARBA00043097};
DE AltName: Full=V-erbA-related protein 1 {ECO:0000256|ARBA:ARBA00042197};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000021132.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000021132.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Nucleus
CC {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR AlphaFoldDB; A0A3Q1IHF8; -.
DR STRING; 64144.ENSATEP00000021132; -.
DR Ensembl; ENSATET00000021490.2; ENSATEP00000021132.1; ENSATEG00000014679.2.
DR GeneTree; ENSGT00940000160548; -.
DR InParanoid; A0A3Q1IHF8; -.
DR OrthoDB; 3475284at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR CDD; cd07166; NR_DBD_REV_ERB; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF113; NUCLEAR RECEPTOR SUBFAMILY 1 GROUP D MEMBER 1; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 125..201
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 419..645
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 1..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 68537 MW; 622C7B531D7BCFF8 CRC64;
MTTPATDTNN NTGGVISYVG SGGGSPTRTS PVSMYSENSN SQPSFTSSSL PASFLSSSSS
SSSSSSSSSS SSSSSSSSSG FAGEDGSSSA SSSAGGSPRG RDDGGSLRAS PSKSVASLTK
LNGMVLLCKV CGDTASGFHY GVHACEGCKG FFRRSIQQNI QYKKCLKNEG CTIMRINRNR
CQQCRFKKCL SVGMSRDAVR FGRIPKREKQ RMLAEMQSAM NNMVNNQLQN DFQLASISSS
CSSLSSSSSS SSSSSPCPGL TIAPQPQPSA VPLLPSSPSP PAPASSSSPP PLPPPPFCQS
PSPSLSSSPP PSPGVDSTIT AVAHAHRETF VYAHDKLTNP HASPRQNNHT HHSGGEAELW
GPNRCPSGYH ANGFNTIYHH NNNLETGRFV PDNSSNITPR HNGNRRRILH NSNLSGGDGL
SDHVTPGQNC PAKNRTGIVL ACPMNMKPHA DPLKTPQEIW EDFSLSFTPA VREVVEFAKH
IPGFGALSQN DQVALLKAGT FEVLMVRFAT LFNMKEQTVT FVSGATYSLV ELQAMGMSEL
LGAMFDFSHK LAALELNADE LGLFTAVVLV SADRSGIENV GSVEQLQENL IRALRSLVNK
SSVAADGDQH NVDSPRFTKL LLKLADLRTL NNMHSEKLLS FRIDA
//
