ID A0A3Q1IKE3_ANATE Unreviewed; 2037 AA.
AC A0A3Q1IKE3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) {ECO:0000313|Ensembl:ENSATEP00000022192.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000022192.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000022192.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR STRING; 64144.ENSATEP00000022192; -.
DR Ensembl; ENSATET00000022557.2; ENSATEP00000022192.2; ENSATEG00000015294.2.
DR GeneTree; ENSGT00940000156187; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546:SF44; DYSFERLIN; 1.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1996..2016
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..81
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 200..315
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 350..486
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1125..1251
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1522..1642
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1748..1896
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 153..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 669..696
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 174..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2037 AA; 233082 MW; 84F1CC2D6C28137B CRC64;
MLMFLHIASG SKKKTKVIKN NPNPVWNEGF EWDLKGIPLD SGAELHCVVK DHEKMGRNRF
LGECRLPLRD VLNSPSLSAT FTVSLLDTKR NNTGVSTHKS IVKQQTINIK SKDCLVSWLF
WLIRYLILSV NAVISLDTLG EEDTESMMML EPPEDLGADD GHSMVIIGPQ GPPGQESPTA
QTPKRSPPSY NTQGGLRKRR RGASSQPKPL PNKPQDLQVR VRVIEARQLP GINIKPVVKV
TLAGQTKRTR IRKGNNPVFD EVNVFFPCFL GPNIKYFFQV CDSRSLRTDA VIGEFKFTIH
CLGHCFLRKW LLLCDPDDFS AGVKGYLKVS LFVLAAGDEP PADKRECVED KEDIEGNLLR
PAGLTLRGAT FTLKIFRAED LPQMDDTFMD GMRQILGFDS NRKNLVDPLV EIHFAGKTIS
TKILEKNANP HWNQSLSMPI RFPSMCEKMR IRIVDWDRAS HNDVIGTTHL CMSKISAPGG
EIDAFMSVSE ACLSHPETNL TFDDSLGFLP TFGPCFVNLY GSPREFTAFN DPHEALNLGK
GEGVAYRGRV LLELTTKLVD KPEQKTEDIS SDDLLTVEKF LRKRKFSLFV AFYSATMLQD
IDDAIQFEVS IGNYGNKFDY TCLPLASTTQ FSRAVFDGCH YYYLPWGNVK PVVVLSSEWE
DIKPRIEALN MLLAIIDRLE LNLQRVRLEV KAGSELEEVE LRVVELLDQV ITDCSEELPS
LDQWQCATPL DRCLRHIRTL HLQQIMAAAL ALKHGEATEL STVMEQAEDW ANRLRTIAEE
PQNSLPDIVI WMLQGDRRVA YHRIPAHTVL FSQQHRGKHC GQLQTVFLKY PQGSGGEAKL
PGQLRVKVWF GLSADVKHFN QYAEGKLSVF TETYENQTRL ALVGSWGTTG LTYPKFSDVT
GRIKLPRESF KPSPGWTWAG DWYISPEKTL LFDVDAGHMN FTEEVFENQM RLPGGQWIGM
PEGYTDVNGE KAVPKDEVEC PPGWAWDDVE WSEDLNRAVD DQGWEYGITI PPDRRPKSWV
PAEKMYHTNR RRRWIRKRQR DQQKMDALRK QRPDEAEREG WEYASLFGWK FHLKPRKTDS
FRRRRWRCRM EPLEKTGPAA IFALECSLSS IEDKNDDKSV TTTFGVNRPT ISCFFDRGTR
YHLRCYLYQA RDLLAMDKDS FSDPYAIVSF LHQSQRTVTV RNTLNPTWDQ TLIFYELEIF
GDPDAMMVNP PNVVVELYDE DTYGADEYMG RCVCQPTFTP SPRLAWFPIR QGDKNAGEML
AAFELIRREK PAIHHIPGQE VHLCFPEESD LPYPPPQREP SVFMVPQGIK PVLQRTAIEI
LAWGVRNLKS FQLASVTSPS LQVECGGTMV QSCVIRSVKK KPNFDVNILI LDVRLPREEL
YMKPVVGQCT IRSLEEYWCN PEQRGALTAG DVFVDIDDEE PLVPDQVKLS FQLGEEFMDW
WSKFYASTGE KNKCGTYLEK GLDTLKVYGQ ELEKVDGFEG LSDFCQTFKL YRGKTQDEGE
DPSVVGEFKG MFKIYPLPDD PSASAPPRQF RMLPPNGIEE CLVRVYIIQA QGLQPKDANG
KCDPYVKITL GKKTISDHEN YIPCTLDPVF GKVFELTCSL PVEKDLRVML YDHDMLTKDE
KIGETVIDLE NRFLSKHGAM CGLPQSYCVS GINQWRDQLT PRQLLLRVCE RRNLRKPVFE
NNVVHFRGDR YTERHLGPIK ERLSLHILRK LGLVPEHVET RPLYSPLQPD IEQGRLMMWV
DLFPKSLGPP GPPFNVTPRK AKKFFLRCII WNTSDVILDD VSISGEKMSD IYLKGWLDGH
EHNKQKTDVH YRSLGGEGNF NYRFLFPFHY LPAEQLCVVD RKEHFWSIDK AETKLAPKLN
IQVWDNDKFS FDDYLGHLVM DLNHMLPPSK SPEKCNLQLL DQPSGRLVSL FEQKTVKGWW
PCTCEQNGEK IIAGKVEMSL EIVTEQEHEE RPAGIGRDEP NMNPHLEEPR RPETSFLWFS
SPYKTLKFIL WRRFKWVIIL FIILFFIFLF LGVFLYSFPN YAAMKLVGPF GPAKSAQ
//
