ID A0A3Q1IPP8_ANATE Unreviewed; 2276 AA.
AC A0A3Q1IPP8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000019678.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000019678.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSATET00000020012.2; ENSATEP00000019678.2; ENSATEG00000013629.2.
DR GeneTree; ENSGT00940000157157; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 24.
DR CDD; cd21702; JMTM_Notch1; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 29.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24033; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24033:SF235; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 17.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 5.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 4.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 29.
DR SMART; SM00179; EGF_CA; 27.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 16.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 17.
DR PROSITE; PS00022; EGF_1; 24.
DR PROSITE; PS01186; EGF_2; 18.
DR PROSITE; PS50026; EGF_3; 29.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 21..61
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 64..101
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 102..138
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 140..178
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 180..217
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 219..255
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 257..295
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 297..333
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 334..372
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 374..419
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 421..456
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 458..494
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 495..527
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 546..582
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 626..664
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 666..702
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 704..740
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 742..778
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 780..816
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 818..854
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 856..892
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 905..940
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 942..978
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 980..1016
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1018..1062
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1064..1102
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1104..1143
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1145..1181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1184..1222
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1246..1286
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1287..1324
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1325..1368
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1724..1756
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1791..1823
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1824..1856
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1857..1889
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1576..1599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1947..1987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2059..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2203..2276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1959..1982
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2059..2077
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2203..2227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2235..2276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 393
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 51..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 91..100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 128..137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 168..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 207..216
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 245..254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 285..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 323..332
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 343..360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 362..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 385..400
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 425..435
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 446..455
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 635..652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 654..663
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 692..701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 730..739
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 768..777
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 806..815
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 844..853
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 882..891
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 930..939
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 968..977
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1006..1015
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1052..1061
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1073..1090
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1092..1101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1133..1142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1171..1180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1193..1210
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1212..1221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2276 AA; 246274 MW; 07C91B1011648000 CRC64;
PPPPPIPLLC PSDYVGNRCQ YPNPCSPSPC RNGGECRAVS HGNTFDFRCV CRLGFTDRLC
LTPTNHACMS SPCRNGGTCD LLTLTTYRCR CPPGWSGKTC QLANPCASNP CANGGQCSAF
ESTYICTCPP AFSGQTCKQD VNECAQTPSA CLNGGTCVNE VGSYHCRCPQ EYTGEHCETP
YTPCSPSPCQ NGGTCIQKGD TTYDCSCLPG FTGENCEHNI DDCPGHNCQN GGVCVDGVNT
YNCQCPPHYT GQYCTENVNE CELMPNACQN GGTCHDTHGS YHCVCVNGWT GDDCSENIDD
CASAACYHGA TCHDRVASFF CECPHGRTGL LCHLDDACIS NPCQKGSNCD TNPVNGKAIC
TCPPGYTGSA CNLDIDECSL GNTPCKNGAK CTDGPNKYTC ECLLNTFYYC LGYTGQHCEI
DINECYSDPC HYGTCKDGLA SFTCLCRPGY TGRLCETNIN ECLSQPCKNG GTCQDRENSY
ICSCPKGTAG ETFDCESNPC MNGGTCKDMT SGYHCTCRPE RIPYYPISNP TVLSNTTTVG
PNCQTNINEC ASNPCLNQGT CIDDVAGYKC NCLLPYTGTI LTSYLFFFLS VLLVVDTTVC
SISITTTMQT LMFSFVFPLG ENCETLLAPC SPRPCKNGGV CKESEDYQSF SCTCPEGWQG
QTCEIDINEC VKSPCRNGAM CHNTMGGYQC KCQPGYTGQK CETDIDDCKP NPCSNGGLCH
DGINSFTCSC PPGFRGSRCE HDINECESNP CKNGANCTDC VNSYTCTCPP GFSGINCEIN
TNDCTDSSCF NGGTCVDGIN AFTCLCLPGF TGSYCQYDIN ECDSKPCLNG GTCLDSYGTY
KCTCPHGYTG VNCQNLVRWC DSSPCKNGGT CWQQGASYTC QCQSGWTGLY CDIPSVSCEV
AAKQQGVEVA HLCRNSGQCL DAGNTHYCRC QAGYTGSYCQ EQVDECSPNP CQNGATCTDY
LGGYSCECLP GYHGVNCSKE INECQSQPCQ NGGTCIDLIN TYKCSCPRGT QGVHCEINLD
DCNPFTDPLT NEPKCFNNGK CVDRIGGYQC VCPAGYVGER CEGDVNECLS DPCDPRGSYN
CIQLTNSYRC ECRTGYTGQR CDKVFDGCKG RPCRNGGTCA VASNTPHGFI CKCPPGFTGS
SCEYDSRSCG SLNCRNGGTC VSGHLGPRCL CPPTFTGPEC QTPTDSLCIS NPCYNGGTCQ
ITPDAPFFQC SCPSNFNGLL CHILDYSFIG GFGRDITPPP EVEVSCEIPQ CDEWAGNHIC
DSLCNNHACG WDGGDCSLNF DDPWQNCSAA LQCWRYFNDG KCDGQCNSPG CLYDGFDCQG
QEGQCNPLYD QYCKDHYADG HCDQGCNNAE CEWDGLDCAN NMPEKLADGH LVLVVHIPPE
QLKNRSSAFL RDLSSVLHTN VVFRRDAKGE PMIFPYYGNE QDLVKHNVLK RSADGWPEWT
AMPANVLGQV KESVSAMVSS RKRRELDPVQ VKGSVVYLEI DNRQCYQQST ECFQSATDVA
AFLGALASSG NLNVPYIEAV TSVRPTPPNT ELYPMYVVFL GLAALGFVCL GVLVSRKRRR
EHGQLWFPEG FKASEPSKKK RREPLGEDSV GLQPMKNSDI NLMDDNQNEW GDDDPDCRSF
RFEEQAMLDL SDHTDHRKWT QQHLDAADLR IASIAPTPPQ GEIENDCMDV NVRGPDGFTP
LMIASCSGGG LETGNSEEEE DPSAEIISDF IYQGANLHNQ TDRTGETALH LAARYARSDA
AKRLLESSAD ANVQDNMGRT PLHAAVAADA QGVFQILIRN RATDLDARMH DGTTPLILAA
RLAVDGMVEE LINCHADANA TDDSGKSALH WASAVNNVEA AIVLLKKGAN KDMQDNKEET
PLFLAAREGS FETAKVLLDH CANREITDHL DQLPRDIAQE RMHHDIVRLL DEYNVVTSPG
LHSAPLSTSS LSPPLCSPND YLSNIKPTLS VKKVRKPSSA GKGGKDGSKD NRMKKKKMDG
KSNLLDTSAV LSPVESLESP HCYLSDVASP PMTSPFQQSP PMSLNHLQGN GDSHMGQMNM
GKDMGCMSFD PNPPRLSHLP VSSPSSQGTT SIGGSRGAQC DWASRMHPGI GQQGSFTQAP
PMPHNIMGSL HGISTATLSQ IMGYQNLQTS HLGSTAHMMQ QAHSRQLQQQ NSNSTTAGQT
INQSFPNIEV NGSDMQPNNS TGRSMPIHTV MPQETQILGT QFLTPPSQHS YSGPMDNTPN
HQVQAPDHPF LTPSPGSPDQ WSSSSPHSNM SDWSEGISSP PTSIHSQMNL IPDQFK
//
