ID A0A3Q1IQ49_ANATE Unreviewed; 1542 AA.
AC A0A3Q1IQ49;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Patched 1 {ECO:0000313|Ensembl:ENSATEP00000023952.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000023952.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000023952.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR Ensembl; ENSATET00000024338.2; ENSATEP00000023952.2; ENSATEG00000016563.2.
DR GeneTree; ENSGT00940000159011; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR InterPro; IPR004766; TM_rcpt_patched.
DR NCBIfam; TIGR00918; 2A060602; 1.
DR PANTHER; PTHR46022; PROTEIN PATCHED; 1.
DR PANTHER; PTHR46022:SF5; PROTEIN PATCHED HOMOLOG 1; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 426..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1104..1125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1157..1182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1194..1218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1224..1243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 425..585
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 684..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1278..1450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..650
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1278..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1349
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1421..1438
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1542 AA; 170716 MW; 36E38091299877B5 CRC64;
MASAASAPSE QESRDPDRPR ITRRSRGNYT RSTPLDLEYL QRPSYCDAGF ALEQISEGKA
TGRKAPLWLR AKFQRLLFRL GCYIQKNCGK FLVVGLMIFG AFAVGLRAAN LETDVEKLWV
EVGGRVNQEL KYTRQKIGEE AMFNPQLMIQ MPREEGANVL TVEALLQHLE SAIQASRVHV
YLYNRQWKLE DLCYKSGELV TETHFMNQII EKLHPCLIIT PLDCFWEGAK LQSGMVYLPK
VQWTNFDPKE FLEELRKANF PVEVFEEMLE KADVGHGYMD RPCLNPADPD CPLTAPNKNS
TKPFDVARAL SGGCHGLSRK YMHWQEELIV GGTTKNGSGP LLSAQALQTM FHLMTPKQMF
EHFQGYDVVS HINWNEEKAA AILEAWQRRY SEAVLQSVTA NSSQKVLSFT TTTLEDILKS
FSDISVIRVA SGYLLMLAYA CLTMLRWDCA KSQGAVGLAG VLLVTLSVAA GLGLCSLLGI
SFNAATTQVL PFLALGVGVD DVFLLAHAFS ETGQNKRIPF EDRTGECLKR TGASVALTSI
SNVTAFFMAA LIPIPALRAF SLQAAVVVVF NFAMVLLIFP AILSMDLYRR EDRRFDIFCC
FYSPCANRVI QIEPQAYLDG ADGSRYSPPP SYRTPPPSYC TPPPSYSSPP PSYSSHGFAQ
QTQITMQSTV QLRTEYDPRT QAFYTTAEPR SQISVQPMNP APTRSNPNND YYSSSTSGTR
SSSSNLNNNN CGMRSNGASR SSASFSHHHP APPTAAQTSN ASSVPQGDAA SSTGQSPENN
SSTRDLLSQF GEASMGLHCL KPPCSRWTLA SFAEKHYAPF LLQPTTKVVV IVLFLSLLGV
SLYGTTQVRD GLELTDIVPR ETSEHDFIGA QFKFFSFYNM YVVTQRADYA QNQPLLHQLH
QRFHTVHYVL KEDNGQLPRM WLQYFRDWLQ GLQQAFDKDW EAGRITLNSY KNGSDDGVLA
YKLLVQTGRR DKPINFNQLT RQRLVDADGI INPGAFYIYL TAWVSNDPVA YSASLANIRP
HPPEWLHDRT DSMPETRLSI PAAEPIEYAQ FPFYLNGLRE TPQFVEAIES VRAICSNYSR
QGLPSYPNGY PFLFWEQYVS LRHWLLLSIS VVLACTFLVC ALFLLNPWTA GIIVLVLSLM
TVELFGFMGL MGIKLSAVPV VILIASVGIG VEFTVHVALA FLTAIGDRHK RAVLALEHMF
APVLDGAFST LLGVLMLAGS EFDFIVNLYY TSLTAALFTF SLLTPQVSPV DGRSRLPTPS
PEAPPHVVHF SVRPHHTAAA TTTSGAASDS SDSEYSSYTT VSGVSQDLQN YNLPSHRGQA
RAEEQQYHHQ TSRGRAARTE EERRAGSGHR RSARQPVPPA YAVSSGCDSG PQPGVTQRNS
SRDPKSQLHW QAPPPAHPRM DAFETATEAG GHYSSHGHRE HSAGHRARSS HNQQPNHHLP
HHHPNPTPYC QPITTVTASA SVTVAVHPPP LSNQSPPASS YTGYTATDNY CSSGPVDPEP
VFQDPHVPLD THTGARGVKV ETMELQDLEF EAAESNSGRR AS
//
