ID A0A3Q1IS58_ANATE Unreviewed; 929 AA.
AC A0A3Q1IS58;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Sodium/calcium exchanger 1-like {ECO:0000313|Ensembl:ENSATEP00000023310.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000023310.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000023310.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
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DR AlphaFoldDB; A0A3Q1IS58; -.
DR Ensembl; ENSATET00000023684.2; ENSATEP00000023310.2; ENSATEG00000016105.2.
DR GeneTree; ENSGT00940000164137; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR032452; Na_Ca_Ex_C-exten.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00845; caca; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR PANTHER; PTHR11878:SF26; SODIUM_CALCIUM EXCHANGER 4 ISOFORM B; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF16494; Na_Ca_ex_C; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..929
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030080042"
FT TRANSMEM 71..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 753..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 830..850
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 901..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 377..477
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 508..607
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 929 AA; 101762 MW; A4D512C998E748BA CRC64;
MSVPPSSLTS PRLPSLLFFL LSLFLLLAFP GSVHASSSGN CSAVGDACQE GVVLPVWNPQ
NPSVGDKVAR AIVYFVALIY MFLGMSIIAD RFMSSIEVIT SQEKEITIKK PNGETTTATV
RIWNETVSNL TLMALGSSAP EILLSVIEVC GHNFEAGALG PSTIVGSAAF NMFIIIALCV
YVVPDGETRK IKHLRVFFVT GAWSIFAYIW LYLILSVFSP GEVEVWEAVL TFLYFPLCVV
QAWVADRRLL FYKYVRKRYR ADKARGIIIE TEGGLDGQMA LNCHSGLDGG MMEEGGAKDE
EDEARRDMAR TLKELKQRHP DKDMEQLIEM ANYQVLMQQQ KSRAFYRIQA TRMMIGAGNI
LKKHAADQAR KVVSSHETQA QEDDPHTVRL EFEPSLYQCF ENCGSLKLSV GRHGGDPGVT
VKVDYRTEDG TANAGSDYEF AEGTLLFKPG ETLKEITVGV IDDDIFEEDE YFYVHLSNPR
VVGYPEIGTA PLDASATPKA VLGDNHTATV TIYDDDHAGI FTFESASQRV SESVGVMEVK
VLRTSGARGL VAVPYRTLDG TAKGGEDYEL AAGKLEFQND ETMKIIEVKI IDDEEYEKNK
TFTIELGEPV LLEIGQKHGE PLFSLCVCVC VQCTVVLSDS NENKPLVGAE EEEVAKMGCP
SLGEHTQLEV IIEESYEFKS TVDKLIKKTN LALVVGSSSW REQFVNAVTV SAGDDDEEES
GEERLPSCFD YIMHFLTVFW KVLFAFVPPT EYWNGWACFI VSISLIGILT AVTGDLASHF
GCTVGLKDSV TAVVFVALGT SVPDTFASKV AAIQDQYADA SIGNVTGSNA VNVFLGIGVA
WTIAAVAWRS KGEAFKVDPG NLAFSVTLFT ILAVVSVVTL LYRRRATVAG GELGGPRTCK
LLTSLLFISL WLIYILLASL EAYCHIPGF
//
