ID   A0A3Q1IV93_ANATE        Unreviewed;       241 AA.
AC   A0A3Q1IV93;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Mitochondrial genome maintenance exonuclease 1 {ECO:0000256|HAMAP-Rule:MF_03030};
DE            EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_03030};
GN   Name=MGME1 {ECO:0000256|HAMAP-Rule:MF_03030};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000024415.2, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000024415.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease
CC       involved in mitochondrial genome maintenance. Has preference for 5'-3'
CC       exonuclease activity. Necessary for maintenance of proper 7S DNA
CC       levels. Probably involved in mitochondrial DNA (mtDNA) repair.
CC       {ECO:0000256|HAMAP-Rule:MF_03030}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03030}.
CC   -!- SIMILARITY: Belongs to the MGME1 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03030}.
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DR   AlphaFoldDB; A0A3Q1IV93; -.
DR   Ensembl; ENSATET00000024809.2; ENSATEP00000024415.2; ENSATEG00000016926.2.
DR   GeneTree; ENSGT00390000003349; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0008297; F:single-stranded DNA exodeoxyribonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0043504; P:mitochondrial DNA repair; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.320.10; -; 1.
DR   HAMAP; MF_03030; MGME1; 1.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   PANTHER; PTHR31340; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; 1.
DR   PANTHER; PTHR31340:SF3; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
PE   3: Inferred from homology;
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_03030};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_03030};
KW   Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03030};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_03030};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040}.
FT   DOMAIN          113..207
FT                   /note="PD-(D/E)XK endonuclease-like"
FT                   /evidence="ECO:0000259|Pfam:PF12705"
FT   ACT_SITE        147
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
FT   ACT_SITE        160
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
FT   ACT_SITE        162
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
SQ   SEQUENCE   241 AA;  27132 MW;  D1D8C244E341A875 CRC64;
     MFILKRVLSA GDILVLQCTS HFARNLSACH CLRSPKKRSP YVSVDSERYS SLVKTVMSSR
     VSSRTPETIQ AEDENIFGPV VKTQTQGNVF HSAVEDILTS GATQQEYPPD VQGYMESISH
     VLEDVRAVRA IESTVQHDTL NYLGIVDCVA YYRGVLCVID WKTSEKPKPF LSNTYDNPIQ
     VAAYAGALNN DGNYKYQVEN GLIVVAYKDG TPAHAHQLSS ELMLEYWNTW LLRLEDFTEQ
     R
//