ID A0A3Q1IWU2_ANATE Unreviewed; 244 AA.
AC A0A3Q1IWU2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dickkopf WNT signaling pathway inhibitor 2 {ECO:0000313|Ensembl:ENSATEP00000022118.1};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000022118.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000022118.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the dickkopf family.
CC {ECO:0000256|ARBA:ARBA00010842}.
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DR AlphaFoldDB; A0A3Q1IWU2; -.
DR STRING; 64144.ENSATEP00000022118; -.
DR Ensembl; ENSATET00000022483.2; ENSATEP00000022118.1; ENSATEG00000015345.2.
DR GeneTree; ENSGT00940000164073; -.
DR InParanoid; A0A3Q1IWU2; -.
DR OMA; SNYICVP; -.
DR OrthoDB; 4329885at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR CDD; cd23015; Dkk2_Cys1; 1.
DR CDD; cd23273; Dkk2_Cys2; 1.
DR Gene3D; 2.10.80.10; Lipase, subunit A; 1.
DR InterPro; IPR006796; Dickkopf_N.
DR InterPro; IPR048500; DIKK1/2/4_C-subdom1.
DR InterPro; IPR048499; DIKK1/2/4_C-subdom2.
DR InterPro; IPR039863; DKK1-4.
DR InterPro; IPR047303; Dkk2_Cys1.
DR InterPro; IPR047302; Dkk2_Cys2.
DR PANTHER; PTHR12113:SF12; DICKKOPF-RELATED PROTEIN 2; 1.
DR PANTHER; PTHR12113; DICKKOPF3-LIKE 3; 1.
DR Pfam; PF04706; Dickkopf_N; 1.
DR Pfam; PF21481; DIKK1-2-4_C-subdom1; 1.
DR Pfam; PF21479; DIKK1-2-4_C-subdom2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..244
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018628195"
FT DOMAIN 71..121
FT /note="Dickkopf N-terminal cysteine-rich"
FT /evidence="ECO:0000259|Pfam:PF04706"
FT DOMAIN 164..193
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 1"
FT /evidence="ECO:0000259|Pfam:PF21481"
FT DOMAIN 196..243
FT /note="Dickkopf-related protein 1/2/4 C-terminal subdomain
FT 2"
FT /evidence="ECO:0000259|Pfam:PF21479"
FT REGION 37..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 244 AA; 27114 MW; B4F608D7D23ADFB1 CRC64;
MLVSTWNRCC VVVFLVATLR TGTSQVSATR PKANAIKPAL LEESPTPATN RSASAQSGTT
KKHNNLQVYP CSNDKECSVG SYCHSPQQTP SRCITCRRRK KRCHRDAMCC PGNRCSNYIC
VPISESVLSP HISALDEPNK LSNKDHNWRK SGKSHAKHSL KGHEGDSCLR SSDCAEGYCC
ARHFWTKICK PVLRQGEVCT KQRKKGSHGL EIFQRCDCAK GLSCKVWKDA TSSSKSRLHM
CQKI
//
