ID A0A3Q1IZ61_ANATE Unreviewed; 1599 AA.
AC A0A3Q1IZ61;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 {ECO:0000313|Ensembl:ENSATEP00000008866.1};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000008866.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000008866.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 64144.ENSATEP00000008866; -.
DR Ensembl; ENSATET00000009025.2; ENSATEP00000008866.1; ENSATEG00000006256.2.
DR GeneTree; ENSGT00940000157424; -.
DR InParanoid; A0A3Q1IZ61; -.
DR OrthoDB; 4835at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08837; ArfGap_ARAP; 1.
DR CDD; cd13259; PH5_ARAP; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 3.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 4.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 9..69
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 487..579
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 595..684
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 690..804
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 898..1004
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1114..1290
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1325..1414
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1427..1541
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 64..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..329
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1599 AA; 181010 MW; B33AEBAC15E6CAA5 CRC64;
MSQSEPCINV WDWLRVLHLE QYSEAFRSAG LATLQQCRNL TPDTLELMGI ILPGHQRRIL
TSLSKTHSHR DTQSNTWSSH AQSEKDQRSE EISHTQVLQR ERPVPIPVEE KLVTRRTDGE
TLRPIPTERE KPVPKERQVS RMKEENLKVG ENKPVAEQRQ TASRIGGVDG EREKPVPKER
TKFRPSAPVD CPPVLIVSSA SDTALPPIPP RSSPNCPPQR FTSALSPSPP PRTPDSPKLD
RHVAKAPAEQ SRSVTQSSTP IHTPTPTPTY ARPQTLAIQP HHQSLVSDEE RKTSPISPTA
FLSDNREAPP LPKKVGGGPK GPPPVPQRSS AQSPSTNSPS PTKTVADEMH QEQTPQVPPR
IRTPQNQEIT QQSSQPETQP ALPARRVCQS PRESRLGSLD NSNDYEDPDF FCLGDHRMNT
PDRDMSLHVP HQLKERKNSL YSDDELLDDE EPTLWQDEGI SSQGSVYLPN TGRQVSATKE
DSSQLTAVIK SGWLDKNPPQ GALYYQRRWV KLDVDYLRYF DSDKDVYSKG IISTAFITNV
TSVGELKFEV ATNNRTFIFR AESEAERNEW VTVLQDCTRG RHHRSSSMNP GSPLTPDHQG
YLELKGLRSK LYTVVSSDKV FLYKNIDDYR IGVGITAIEM NVGNIKDTDR RSFYLTTPYR
IFSFIAESEQ LKGQWVDAMR NAIGEALSNS EVADQIWAEP SNSFCADCGA PKPEWAAINL
CVVVCKRCAG EHRGLGPSIS KVRSLKMDKK VWTEELVQLF LVLGNERVNS FWAANVPPSE
ALTLSSCSED RRRFITNKYR QGKYRRYHPL YGNQTELNNA LCINVQGSDV LETLSLIFCG
ANVNCSTGMT AWPTPLSLAK AHSQSLQAEL INHNLNTELP RLDVGGDMEA KHYSPPPCVS
YNGFLFKTAS MARAPERKAR EEFSRRWCTL NDGTFSYFES DKNSNPNGAL KAPEIVCMTV
DTPGKHGYEN TFELYSESER LYLFGTDEPD SHKEWVKSIA KCFIPAAAEP LLRLSFERIG
RLKYKDGLNL QTSKVGWFAL VGSTLHAYME HSQAEEIHLR KLNELSIQQD NEVLVLVEKG
RTLYIEGERK LDFAGWCGAI QAAAGSGGDT LSQQQLTETD IPIIVHSCIY YITQCGLTSE
GIYRKSGVNS RVAALCDRFR QDARSLRLKE GEHQVDDVSN TLKRFFRELE EGLFTSEDGK
TWLSAAGIQD ESTKISQYKL LLNRLPLVNR ATLQALINHL YCVQRFSDKN QMNLHNLAIV
FGPTLFQTDG KDYTAGRAIE DLIQHYTLIF EVDEQQLKKQ LDEIIAILKV RETLSTKFPS
TEPGGHFICT VYLEEKKDTA EQHVKIPGSM TAAELTCEVL DLRNIPVKEK DYWSCWEVSE
KEEMERPLHY QERVLPILHS SGTDSHLLIK KHHAMDLMID YLANKGDASK HGMIKFREEK
SILGLGLTSG NFHDRYFILN SNSLRMYKDV RSNRPERDWP VKNLKVYLGI KKKLRPPTCW
GLTVLYESKK QEKPERQQWH LCFETQSELR EWYATFLSIQ YDGNVWPQDG LQQTRVSRVL
PESRHGNVSL IPLRGSENEM RNSVAAFSQD LLALFRDVR
//
