ID A0A3Q1J3H6_ANATE Unreviewed; 1038 AA.
AC A0A3Q1J3H6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Solute carrier family 12 member 1 {ECO:0000313|Ensembl:ENSATEP00000025934.2};
GN Name=SLC12A1 {ECO:0000313|Ensembl:ENSATEP00000025934.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000025934.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000025934.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q1J3H6; -.
DR STRING; 64144.ENSATEP00000025934; -.
DR Ensembl; ENSATET00000026353.2; ENSATEP00000025934.2; ENSATEG00000017929.2.
DR GeneTree; ENSGT00940000158030; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF93; SOLUTE CARRIER FAMILY 12 MEMBER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 155..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..89
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 154..644
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 653..1038
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1038 AA; 114507 MW; CF7731B32A54C17E CRC64;
MERFKSKGGE HINPSYDSTL DEPPVYEESN FSNGEHRAVR PSVVSAFGHD TLDRMPNIDF
YRNAGSVSGQ RAVRPSLQEL HDVFQKVRAC TLYNFTYFIC LILPLHTLQN GAISVPDTVE
DDGQDSDGAP SDDLESAIPS DSDKGAVKFG WIRGVLVRCM LNIWGVMLFI RLSWVFGQAG
WGLGIVVVAL SCVVTTITGL SMSAICTNGV VRGGGAYYLI SRSLGPEFGG SIGLIFAFAN
AVAVAMYVVG FAETVVDLMK EHAAIMVDET NDIRIIGCIT VVLLLAISVA GMEWEAKAQV
LLLIILLVAI VNVFVGTVIP ATADKKSKGF FNYNSKVFSE NFLPAFRDGE TFFSVFAIFF
PAATGILAGA NISGDLRDPQ GGLPKGTLLA ILITGVTYLA VALCVSATVV RDATGNTTDL
ITPGVPCNGS AIVCISKLYS MLSVMTMVSG FGPLIIAGTF SATLSSALAS LVSAPKVFQA
LCKDNIYKAL HFFAKGHGKN NEPIRGYVLT FVISVAFILI GDLNAIAPII SNFFLASYAL
INFSCFHASY AKSPGWRPAY KYYNMWLSLL GAVLCCVVMF VINWWAALLT YGIEILLYIY
VTVKKPDVNW GSSTQAVTFV SAVNNALSLS GVEDHVKNFR PQMLVLTGSA RTRPALLDLA
HSFSKNFGLC LLCEVFVGPR AKALEEINAN MEKNQVWLRK TNRKAFYTAV ACDSFGEGAE
RLLQASGLGR MRPNTLMIGF KRNWRTAVTN THKYGTVVLR MNQGLDVSHI IEAEEEMLKA
AKEQQELENE MNGNREKPRG LFRKSRKSSQ QVLTTRGILC SPPPPQVAKM NERLLEASTQ
FKKKLPKGTI DVWWLFDDGG LTLLLPYILT TRKKWKDCKL RIFIAGQPGR SDLDKEEMKS
LLQKFRITCS DVNVIDDIHV KPSSDSWRKF EEMIEPFRLY EGSKDTVQAE AMQKEQPYKI
TDKELNTFED KTNLQIRLNE VIQENSKSAN LIIVSMPIAR KESVSSYLYM AWLDILTMNL
PPTLLIRGNH KSVLTFYS
//
