ID A0A3Q1J675_ANATE Unreviewed; 1079 AA.
AC A0A3Q1J675;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Solute carrier family 12 member 7b {ECO:0000313|Ensembl:ENSATEP00000028335.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000028335.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000028335.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q1J675; -.
DR Ensembl; ENSATET00000028776.2; ENSATEP00000028335.2; ENSATEG00000019481.2.
DR GeneTree; ENSGT00940000157657; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 76..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..477
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 537..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..258
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 370..652
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 666..783
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 785..925
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 968..1079
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 896..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 896..919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..937
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1079 AA; 119668 MW; 59A705197C356CD4 CRC64;
KENSPFINNT ENDKGSSYDG TNMALFEEEM DSNPMVSSLL NKLANYTNLT QGAHEHEEAD
DDEGSKKKAV KSPQMGTFMG VYLPCLQNIL GVILFLRLTW IVGTAGILES LVIVGLCCSC
TMLTAISMSA IATNGVVPAG GSYYMISRSL GPEFGGAVGL CFYLGTTFAG SMYILGTIEI
LLTYIVPKAA IFVATRKEDE VDALLNNMRV YGSCCLAMMA VVVFVGVKYV NKLALVFLAC
VILSILAIYA GVIKTIFEPP DFPVCMLGNR TLQNHNFDKC LKTEVIDNIT VTTKLWTLFC
EGPELNATCN EYFTNNNVTV VQGIPGLTSG VISDNMWSEY GPLDMLVENK KLPSFGGSDP
AKDIYMPYVV NDIMTFFTLL VGIYFPSVTG IMAGSNRSGD LRDAQKSIPI GTILAIATTS
VIYISCVVLF GACIEGVLLR DKFGDSVKGN LVIGTLSWPS PWVIVIGSFF SCCGAGLQSL
TGAPRLLQAI ARDGIVPFLQ VFGHGKANGE PTWALLLTAG ICEIGILIAS LDSVAPILSM
FFLMCYLFVN LACAVQTLLR TPNWRPRFKY YHWALSFLGM SLCLALMFIS SWYYAIVAMV
IAGCIYKYIE YRGAEKEWGD GIRGLSLNAA RYALIRLEDA PPHTKNWRPQ LLVLLNLDSD
QGVKHPRLLS FCTQLKAGKG LTIVGNVIEG TYLTKETEAK KAEQNIKASM SAERTKGFCH
VVVSSNLRDG VSHLIQSAGL GGMKHNTVLM AWPGTWKQSN DPQSWRNFTE TVRETTAAHQ
ALLVAKNVDS FPTNQDRLGE GTIDVWWVVH DGGMLMLLPF LLRQHKVWRK CKMRIFTVAQ
LDDNSIQMKK DLQMFLYHLR LNAEVEVVEM HDNDISAFTY EKTLVMEQRS QMLKQMHLSR
TEREREIQSI TDESRSSIRR KNQGAAQSTN LSRQSSPMED TQEDEVAQLI HDRNTASHAT
LNDKADTGPE RVHMTWTKDK LFTERNRNRE CNANMAVRDL FNMKPNQSNV RRMHTAIKLN
EVVVNKSQGA HLVLLNMPGP PKNRGGDENY MEFLEVLLEG LNRVLLVRGG GREVITIYS
//
