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Database: UniProt
Entry: A0A3Q1J789_ANATE
LinkDB: A0A3Q1J789_ANATE
Original site: A0A3Q1J789_ANATE 
ID   A0A3Q1J789_ANATE        Unreviewed;      1040 AA.
AC   A0A3Q1J789;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=phosphatidylinositol-4,5-bisphosphate 3-kinase {ECO:0000256|ARBA:ARBA00012010};
DE            EC=2.7.1.153 {ECO:0000256|ARBA:ARBA00012010};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000026238.1, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000026238.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-3,4,5-trisphosphate) + ADP + H(+); Xref=Rhea:RHEA:21292,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57836,
CC         ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.153;
CC         Evidence={ECO:0000256|ARBA:ARBA00023981};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21293;
CC         Evidence={ECO:0000256|ARBA:ARBA00023981};
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylinositol phosphate
CC       biosynthesis. {ECO:0000256|ARBA:ARBA00004805}.
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR   AlphaFoldDB; A0A3Q1J789; -.
DR   STRING; 64144.ENSATEP00000026238; -.
DR   Ensembl; ENSATET00000026657.2; ENSATEP00000026238.1; ENSATEG00000018121.2.
DR   GeneTree; ENSGT00940000159079; -.
DR   InParanoid; A0A3Q1J789; -.
DR   OMA; HDPEVND; -.
DR   OrthoDB; 10350at2759; -.
DR   UniPathway; UPA00220; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0046934; F:1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd08693; C2_PI3K_class_I_beta_delta; 1.
DR   CDD; cd00872; PI3Ka_I; 1.
DR   Gene3D; 3.10.20.770; -; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR002420; PI3K-type_C2_dom.
DR   InterPro; IPR003113; PI3K_ABD.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR000341; PI3K_Ras-bd_dom.
DR   InterPro; IPR015433; PI_Kinase.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR10048:SF35; PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00792; PI3K_C2; 1.
DR   Pfam; PF02192; PI3K_p85B; 1.
DR   Pfam; PF00794; PI3K_rbd; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   SMART; SM00142; PI3K_C2; 1.
DR   SMART; SM00143; PI3K_p85B; 1.
DR   SMART; SM00144; PI3K_rbd; 1.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS51547; C2_PI3K; 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51544; PI3K_ABD; 1.
DR   PROSITE; PS51546; PI3K_RBD; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          16..105
FT                   /note="PI3K-ABD"
FT                   /evidence="ECO:0000259|PROSITE:PS51544"
FT   DOMAIN          187..277
FT                   /note="PI3K-RBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51546"
FT   DOMAIN          320..477
FT                   /note="C2 PI3K-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51547"
FT   DOMAIN          498..675
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          742..1023
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   1040 AA;  119978 MW;  CBD79EAE7EBA3B54 CRC64;
     MPPGKYGMQG EWEKEGDHEI MMDFLLPTGI FLKFPVSRND TIKTIKRMVW KNARSEALFT
     ALGDPDAYVF TCINHTAERE ELEEESRRIS DVQPFMCVLR LVAREGDRVE KLTNAQISLL
     IGKGLHEFEV QKNHEVNEFR TKMRVFCEEK AQERQRLPWH QWMEYSFPCD LEPCCSPQCG
     SSRSKNTKKI LINIKFEASD ESFMLQQDPQ DPPLVLMRSA LKKKATVFRS VRQEPEDYTL
     QVNGRWEFIY GNHPLCQFKY IFSCLRNGQN PHLIMVHHST ISKYQEEQGR MCNQVYKSCS
     LSRPPPLPLK KQNTSSLWSI NEPFCIHLVQ GSRVNADEGM KLVVQAGLFH GSELLCKVVT
     SSEVTVCSEP LWDQKLEFDI NVADLPRMGR LCFALYAVIE KAKKPRGTKK KNKKADCPIA
     WVNTMVFDYK DQLKTGEFLL STWPSVPDDK SDLLNPMGTV ERNPNVDSAA GLLIRFANIR
     PYPLYYPPLD KISDVERNGD ATTGTKEEFV KLKEIMDNKN YTEFFEDEKE LLWKLRAEVR
     SSYPESLSKL LLITKWNKRE DVVQMVSLLR NWPDLPAIHA LELLDYSFPD PAVRSFTIRC
     LRNLSDDELL QYLIQLVQVL KYESYLDCDL TTFLLERALS NRRIGHFLFW HLRSEIHVAS
     VSLRFGLILE AYCRGNIHHI RLLTKQNEAL AKMKSLSDFV KSGSQKMTVE DLKLCIRQES
     YLEALSDLLS PLNPSIILSG ICADKCRFMD SKMKPLWLMY KNPGTQGDMV GIIFKNGDDL
     RQDMLTIQMI QLMENLWKKE GLDLRMIPYG CLSTGNKTGL IEVVKNSDTI ANIQRNCSNS
     AATAAFNKDA LLNWLKSKNP GDKLDQAIEV FTLSCAGYCV ATYVLGIGDR HNDNIMIRET
     GQLFHIDFGH FLGNFKRKLG INRERVPFIL TYDFVHVIQQ GRTNNSEKFE RFREYCERAY
     KILCRNGTLF VNLFAMMKAA GLPELTSFKD IQYLKDSLCL GKSDDEALKN FKVKFNEALR
     ESWKTKVNWM MHSLAKDNRP
//
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