ID A0A3Q1JDR9_ANATE Unreviewed; 1113 AA.
AC A0A3Q1JDR9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Potassium voltage-gated channel subfamily H member 2 {ECO:0000256|ARBA:ARBA00013838};
DE AltName: Full=Ether-a-go-go-related gene potassium channel 1 {ECO:0000256|ARBA:ARBA00030015};
DE AltName: Full=Voltage-gated potassium channel subunit Kv11.1 {ECO:0000256|ARBA:ARBA00031970};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000029089.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000029089.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. H (Eag) (TC
CC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00007076}.
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DR AlphaFoldDB; A0A3Q1JDR9; -.
DR Ensembl; ENSATET00000029534.2; ENSATEP00000029089.2; ENSATEG00000019922.2.
DR GeneTree; ENSGT00940000159846; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10217:SF506; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 2; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00086; PAC; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50113; PAC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 432..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 568..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..144
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 761..861
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 227..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..248
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 125400 MW; 2880A802AB666DCA CRC64;
MPVRRGHVAP QNTFLDTIIR KFDSQSRKFL IANARVENCA IIFCNDGFCH MCGYSRAEIM
QKPCTCNFLY GPDTKRLAIA QMAQALLGSE ERKVEINLYH KDGQCFLCMV DVVPVKNEDG
LVIMFILNFE VMTEETLRDR KQELNHRLPT WLVTGRPRGF KLRFPLLRSL SNSKVSLDDA
EAGHIPTATP LPHCWLTDTC CCLHSFLIFR SVLQRWPEDR QEDQRILLGS EPPPLPPPPS
PPPLPHGVHL VGPLTQSSPC VAPTHHRLSL NPDASGSNCS LSHSRSRESF HSMRRASSVD
EIEAMRSDWD RKNRRASIRP SSSSTGAVNS KSNILNSTSD SDLMRYRTIS KIPQITLNFV
DFKPDPLIAL PTGEMDIIAP CKLIDRTHNV TEKVTQVLSL GADVLPEYKL QAPRIHKWTV
LHYSPFKAVW DWLILLLVIY TAILTPYSAA FLLNYQEEAA MQRCGYSCSP LNVVDLIVDI
MFIIDILINF RTTYVNSNDE VVSHPVRIAV HYFKGWFLID MVAAIPFDLL IYRNGEETTT
LIGLLKTARL LRLVRVARKL DRYSEYGAAV LFLLMCTFAL IAHWLACIWY AIGNVEKNGS
IGWLHTLGDQ LGKHYNDSIP GSGPSIKDKY VTALYFTFSS LTSVGFGNVS PNTNSEKIFS
ICVMLIGSLM YASIFGNVSA IIQRLYSGTA RYHTQMLRVR EFIRFHQIPN PLRQRLEEYF
QHAWSYTNGI DMNAVLKGFP ECLQADICLH LNRTLLQNCK AFKGSTKGCL RALAMKFKTT
HAPPGDTLVH AGDVLTALYF ISRGSIEILR GDVVVAILGK NDIFGEPINL YSRPGKSNAD
VRALTYCDLH KILREDVLEV LDMYPEFADH FWSNLEITFN LRDTNMIPGS PSSDDSNCGG
FNKLRRRKLS FRRRTEKGNE SSMALVMLRS FILLLYILKI QVITGFLCLR NVTLVVIFPS
MIIIREEYPH TLVSAQTNTH PLHLHLSSSP AGAFSGVSNI FSFWGESRGG GQYQEIPSCS
LASPPPLNTP MHSLSRQQRN QLDTRLDLLQ KQLNRLESRM SADIGAIMQL LQRQMSLVPP
AYSAVSSPPQ RLVQPVTPLE TDTLASLSQV KHL
//
