ID A0A3Q1JF02_ANATE Unreviewed; 900 AA.
AC A0A3Q1JF02;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Glutamate receptor, metabotropic 6b {ECO:0000313|Ensembl:ENSATEP00000013656.1};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000013656.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000013656.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; A0A3Q1JF02; -.
DR STRING; 64144.ENSATEP00000013656; -.
DR Ensembl; ENSATET00000013874.2; ENSATEP00000013656.1; ENSATEG00000009522.2.
DR GeneTree; ENSGT01030000234648; -.
DR InParanoid; A0A3Q1JF02; -.
DR OMA; EACPRDM; -.
DR OrthoDB; 5388627at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15286; 7tmC_mGluR_group3; 1.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001786; GPCR_3_mGluR4.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF170; GLUTAMATE RECEPTOR, METABOTROPIC 6B; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01054; MTABOTROPC4R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..40
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 41..900
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018782077"
FT TRANSMEM 594..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 706..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 791..813
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..855
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 594..868
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 880..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..900
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 900 AA; 100545 MW; CD5CC23BF2E6B92C CRC64;
MTSEAHSSHQ CCWFGSPRGY RIWSRLLWVL LLGIIPGSLA QQGTQPQSIK IEGDITLGGL
FPVHSRGPAG IPCGEIKREK GIHRLEAMLY ALDQINSDPD LLPNITLGAR ILDTCSRDTY
ALEQSLTFVQ ALIQKDNSDV RCSNGEPPII PKPERVVGVI GASGSSVSIM VANVLRLFAI
PQISYASTAP ELSDNSRYEF FSRVVPPDSY QAQAMVDIVK AMGWNYVSTL ASEGNYGESG
VDAFIQISRE AGGLCIAQSI KIPREPRPGE FDKIVKRLME TSNARGVIIF ANEDDIKRVL
QAAKKANLTG HFLFVGSDSW GAKNSAIEDH EEVAEGAVTI LPKRASIDGF DQYFTSRSLE
NNRRNIWFAE FWEDDFKCKL TRPGVKYEPG RRKCTGEERI SRDSQYEQEG KVQFVIDAVY
AMAHALHSMH LDLCPGSMGV CEKMDPVEGR MLLQYIRSVN FNGSAGTGVM FNENGDAPGR
YDIFQYQLSN VSNPGYKVIG QWTNHLRLNP EEMQWSGGDH KIPESVCSFP CESGERKKMV
KGVPCCWHCE LCDGYQYLLD EFTCDMCPFD MRPLKNRTGC RPTPIIKLEW SSPWAIIPVF
LAILGILATT GVIVTFVRFN DTPIVRASGR ELSYVLLTGI FLIYLITFLM IAEPSVVVCA
FRRLFLGLGM CISYSAMLTK TNRIYRIFEQ GKKSVTPPKF ISPTSQLIIT FILISVQLFG
VFIWFGVMPP HTIIDYEEQK PPNPEFARGV LKCDMSDLSL MLCLSYSIVL MITCTVYAIK
SRGVPETFNE AKPIGFTMYT TCIIWLAFVP IFFGTAQSTE KMFIQTTTLT VSMSLSATVS
LGMLYIPKVY VIIFHPEQNV QKRKRSFKAI VQAATVSTHL SQKSSEKHNG ESKVETDRSQ
//
