ID A0A3Q1JL20_ANATE Unreviewed; 839 AA.
AC A0A3Q1JL20;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 {ECO:0000313|Ensembl:ENSATEP00000035857.1};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000035857.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000035857.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family.
CC {ECO:0000256|ARBA:ARBA00005430}.
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DR AlphaFoldDB; A0A3Q1JL20; -.
DR STRING; 64144.ENSATEP00000035857; -.
DR Ensembl; ENSATET00000036371.2; ENSATEP00000035857.1; ENSATEG00000024642.2.
DR GeneTree; ENSGT00940000158956; -.
DR OMA; PLGHQLW; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08854; ArfGap_AGAP1; 1.
DR CDD; cd04103; Centaurin_gamma; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR45819:SF3; ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45819; CENTAURIN-GAMMA-1A; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 334..561
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 582..702
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REPEAT 749..781
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 240..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 90827 MW; 14B19131A35F6D8D CRC64;
MNNNSKSVNS TAIKAEIKRH ESLQSAINRL FKQFERVQDQ QLRSGLKVFL TSIQVNIANS
QEWTLNRSVP ELRLGILGSL KSGKSALVNK YITGSYSALE KPDGGRYKKE VLVDGQSYLL
LIREEPGPPD AQFSSWVDAV ILVFSLENEA SFQELYQLYS QLSAFRTDIP VIVVGTQDKI
SSTNPRVIED QRARQLCLDV RHSLFYETCA TYGFNVDRVF SEAAQKIVAQ KKQAALQACK
SLPNSPSHSG GSTPGSASLP GQASNGPSSG YAYSLPSTPV VGHRELRVAQ GEGGGSINAR
SLKSIPRRPS LFKNRDPDKK ASDAKGDLSS VRGVPIKQSI LWKRSGSSLN KEWKKKFVTL
SNNGTLSYHS SSSDYTQNIH GKEIDLLRVT VKVPGKRPPR AVAPVGPSPV PPGSVPGVNG
LNKDLTAADG TSTASVPQLC PATLSVVDDR AGALSPQGGE RGLQRCPSSL STKAQSVDAL
EATASLFGGK DQGQSSPMSD RKKNRRKKSM NQKGDAAVGQ AEDEENADFI IVSFTGQTWH
FEAQSLEERD SWVSAIESQI LASLQSCESG RNKARRSSQS EAVALQAIRN AKGNSLCVDC
EAPNPTWASL NLGALICIEC SGIHRNLGTH LSRVRSLDLD DWPGELTQVL AAIGNHLANS
IWESCTQGRT KPAPNATREE RESWIRAKYE QRAFVAPLQP ALGTQMPEDS MPEWLVSAVT
EKDLPRLLLL LAHSTKEQIN SQPAGSSSLP QTALHAACQQ GDVVMTQLLV WYGIDVRGKD
NQGQTAIMIA RKTGSKGCID ILLQHGCPNE TSPTTATPIL SRRSSTASLG RTSSRKRVT
//