ID A0A3Q1JS94_ANATE Unreviewed; 570 AA.
AC A0A3Q1JS94;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSATEP00000033943.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000033943.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000033943.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
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DR AlphaFoldDB; A0A3Q1JS94; -.
DR STRING; 64144.ENSATEP00000033943; -.
DR Ensembl; ENSATET00000034435.2; ENSATEP00000033943.2; ENSATEG00000023341.2.
DR GeneTree; ENSGT00530000063725; -.
DR InParanoid; A0A3Q1JS94; -.
DR OrthoDB; 4221421at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR PANTHER; PTHR46096:SF5; PERFORIN 1.3-RELATED; 1.
DR PANTHER; PTHR46096; PERFORIN-1; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00457; MACPF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 3: Inferred from homology;
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..570
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030080569"
FT DOMAIN 28..372
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 395..511
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
SQ SEQUENCE 570 AA; 63466 MW; 494A44FB386E399E CRC64;
MIKLWQLMLL WWAWSPLCLS SNVSLTGTPQ ECENAHFVPG YNLGGEGFDI VTMERKGAYV
IDTETWNLGN GTCKMYRNSY MNRENQKVPV GVVDWRTLPK CSLKVSSTVY DSVESLVNDS
TSSVSNDWKV GLEIPVDPSV TVGVGFGGSH SRDATFGMQK SKQDRYNFFR HAVFCSFYSY
RLATNPPLSQ EFKSAVNSLP AYSRKTEEFY RNLIDTYGTH YIIKVSLGGE IKAITSVRTC
EATMNGLSAT EISDCLSVEA SASFAKSASI NAMYKHCQAK KKTLGSHQSF SSTYNERNTE
VIGGHIDSAD ILFQSQSDPS VYGSWLSSLK HTPDVVQYSI KPLHTILPRG HPASAGLKQE
VEKYIKKNAV LKKCSESCQI GHRSSKRDPC DCVCNSNQNI KSNCCPAGKG LATLKVFKLY
AQGLYGDKWT QTDGSVEVSY GEQKKRTIII SNNDNPKWPE TFEFGSISIN MKDRLKFRVY
DEDTYWNSDL LGECSIELHE GKVSDSCMLK HGTLFFSYIV ECAPSLSGDQ CQEYTPSPMS
PSLAKMFYTR NGVLLGESEE QVAISVIQSD
//
