ID A0A3Q1JUL6_ANATE Unreviewed; 4419 AA.
AC A0A3Q1JUL6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Dynein heavy chain 9, axonemal {ECO:0008006|Google:ProtNLM};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000034849.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000034849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 64144.ENSATEP00000034849; -.
DR Ensembl; ENSATET00000035356.2; ENSATEP00000034849.1; ENSATEG00000023933.2.
DR GeneTree; ENSGT00940000154076; -.
DR OMA; ITMDAHG; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF4; DYNEIN AXONEMAL HEAVY CHAIN 17; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040}.
FT DOMAIN 195..765
FT /note="Dynein heavy chain tail"
FT /evidence="ECO:0000259|Pfam:PF08385"
FT DOMAIN 1225..1631
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1765..2091
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2249..2366
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2584..2683
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2728..2987
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3000..3343
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3370..3587
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3828..3948
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3980..4116
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4122..4417
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 2992..3043
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3222..3263
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3577..3607
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4419 AA; 504266 MW; D57D327780FAF402 CRC64;
MRRADAEDMD ESPAEDKRLD VIADYVLRTL KLKQDRWQKC VSSEDNRQVL QEFVDKAESR
TLVVAVTAAG LLQPAASFTG SSSRNKAVYF MKRSQTALSP ESMRDNLVCG DLSYAPLDQF
SALVEEVVAP LLSNSRNHTE WPQVVSQDIL RHVHSLKTGV FVVSGQVQGK TLLPLPAGAE
RVEQAEGEVV DKSIIHSLES AVIEWSHQIR AVLKKDSSEA LLEGRNPTPH TELLFWKNRY
ADLECIHSQL KSPKVNKMAM VLEAVESSYS PAFLNMQQDV LAALEEAEDI CTYLRPLQCL
FEDIENVEFP DVRRQIAPLM HTVCLVWANS RYYNTPGRLI VLLQETCNLL IQQVSMYLVA
EELLKGEVSE SLLKVQTSLE VLQLFRSTYD ECRANLSQYQ RNGSIVRPWD FSPLLVFSGF
DYFIKREILL TAVDLLKLEK LEIGGVRGRA LSQQVQLLHQ EFMDIYKFFT EKSYDCLDLN
NREFEGDVRE FKLKVDDTDR RLGAIFCQAF DDASGLEHAF KVLDMFGSLL ERPLVAADAL
DRYPNLVFMF DKELDCCKVL YNKHIQSAEA LGSASVNKNM PPVAGGLRWA QDLQQRIQTP
FSKFRHLTYP CLESAEGARV IQKYEEMMQL LDRYSTSLYD TWTETVGESS QYNLSLPLIS
RDPTTQLISV NFNPQLASVL REVKYLEARQ TEAIPEAAVQ IYTTRGQLWQ YVANLELTVS
RYNKVMHSLL NVELPLLQSQ LRDIDAQLKK AEESLNWNSQ GIWQYIQEVR DSVCDLESRL
QRTKDNVEEI QSCMRSWANP IFDRKEGKKD TLLGLEDKTE RLDRFYTSHF AIIECSLRFF
LDNTDQRAVV APLFEAQLDL RVPDMVFTPS LEFGAGDSFF ELVECLINDV FRISSLVPRV
AQHSPCPHYQ VLLDMADLAD MRHLLMERVQ VAMASCCEFR NSLDHYSYLY VDDRKEFMRQ
FLLYGHVLNS QEMEVYADDG VLESPPTLDN FREQVDRYEK IYEEVQCLEP VHVFHGWMKV
DGRTMKSALL NIIKKWSFMF KQHLIDHVTN SLSDLEKFIS VAEAGLGLRV EEGDYSVLVG
VMGHLLAVKE RQNNTDAMFE PLKQTIALLK VYEQELPDVV YKQLEVLPEK WNNVKKQAMI
VKQQVAPLQA IEVASLRRKC ASFDVEQFTF REHFRQNGPF RFESENPYQM LDLFHRQIQE
REAVMASLVE SANLFEVTIS EYKQLRQCRR EVGLLKELWD MITVVDSSMA AWKTAPWREI
HVEDMELECK RFSKDIRGLD KEVRAWEAFT GLDSRVKNLL TSLRAVAELQ NPAIRARHWH
QLMAATGVRF TMDQETTLAD LLQLNLHCFE DEVRGIVDKA VKEMGMEKVL SELNATWTGM
QFQYEPHHRT HVPLLRTDEE LIETLEDNQV QLQNLMSSKY IAHFLDEVSL WQSKLSVADS
VISIWFEVQR TWTHLESIFI GSEDIRSQLP EDSRRFEGID ADFKELANAM HQTTNVVEAT
NKPGLFGKLE DIQSRLSLCE KALAEYLDTK RLAFPRFYFI SSADLLDILS NGTNPHQVQK
HLSKLFDNMA KMRFEADGEG NPCKTGLGMY SKEEEYVPFN QPCDCTGQVE VWLNRVLDTM
RSTVRHEMTE AVMAYEDKPR EQWLFDYPAQ VALTCTQIWW TSDVGIAFAR LEEGYDNAMK
EYYKKQVSQL NTLISMLIGQ LTPGDRQKVM TICTIDVHAR DVVAKMIAQK VENSQAFVWL
SQLRHRWGEK EKHCFANICD AQFLYSYEYL GNTPRLVITP LTDRCYITLT QSLHLTMSGA
PAGPAGTGKT ETTKDLGRAL GIMVYVFNCS EQMDYKSCGN IYKGLAQTGA WGCFDEFNRI
SVEVLSVVAV QVKSIQDAIR DKKQRFNFMG EEVNLCPSVG IFITMNPGYA GRTELPENLK
ALFRPCAMVV PDFELICEIM LVAEGFINAR VLARKFITLY TLCKELLSKQ DHYDWGLRAI
KSVLVVAGSL KRGDPGRAED QVLMRALRDF NIPKIVTDDM PVFMGLIGDL FPALEVPRKR
DFDFEKHVKE SILDLKLQAE DNFVLKVVQL EELLAVRHSV FVIGNAGTGK SQVMRSLQRT
YQNMKRRPVW ADLNPKAVTN DELFGIINPA TREWKDGLFS SIMRELANIS HNGPKWIVLD
GDIDPMWIES LNTVMDDNKV LTLASNERIP LNPTMRLVFE ISHLRTATPA TVSRAGILYI
NPADLGWNPA VSSWIDRREV QSEKANLTIL FDKYLPACLD TLRLRFKKII PIPEQSMVQM
LCYLLECLLT PENTPPDCAK ELYELYFVFA AVWAFGGAMF QDQLVDYRVE FSKWWVTEFK
TIKFPSQGTV FDYYIDPESK KFEPWSKMVP RFEMDTDTPL QACLVHTTET IRVRYFMDRL
LEHRRPVMLV GNAGTGKSVL VGDKLASLDA EKYMIKNVPF NYYTTSAMLQ AVLEKPLEKK
AGRNYGPPGS RRLIYFIDDM NMPEVDAYGT VQPHTLIRQH MDYNHWYDRN KLLLKEIHNV
QYVSCMNPTA GSFTINPRLQ RHFSVFALSF PGAEALSTIY TSILSQHLRG EGFTAALQKS
CPALVQLALA VHQHVSSTFL PTAVKFHYIF NLRDLSNIFQ GILFCTGECL KAPQDLLKIF
LHESCRVYRD KLVEEQDFQV FDKLQADTVK KFHEDMEETL EQAREMNLYC HFARGLGEAR
YMAAESWSSL NKTLLEVLDS YNEVNATLNL VLFEDAMAHI CRINRILESP RGNALLVGVG
GSGKQSLTRL AAFISNLEVF QITLKKGYGI ADLKVDLASL YIKAGVKNIG TVFLMTDAQV
ADEKFLVLVN DLLASGEIPD LFPDDEVESI IGSVRPEVRS SGLMDTRENC WKFFIDRVRR
QLKVALCFSP VGSKLRVRSR KFPAVVNCTA IDWFHEWPQE ALESVSFRFL QEVENIEPQV
KDSVSKFMAY VHTSVNQTSK EYLATERRYN YTTPKSFLEQ IKLYRSLLGQ KSKDLTTKME
RLENGLQKLN STSVQVDDLK AKLAAQEVEL KQKNEDADKL IQVVGIETEK VSKEKAVADE
EEQKVAAIAV VVSGKQRDCE EDLAKAEPAL LAAQDALNTL NKNNLTELKS FGSPVAAVTN
VTAAVMVLMA PGGKVPKDRS WKAAKVMMAK VDAFLDSLIN FNKENIPEAC LKAIQPYLQD
PEFQPDLVAS KSYAAAGLCS WVLNIVKFYE VYCEVEPKRQ ALSKANAELA AAQEKLAAIK
NKINHLNENL AKLTAKFEKA TTDKLKCQQE AESTARTISL ANRLVGGLAS ENVRWAEAVE
NFKKQERTLC GDVLLITAFI SYLGYFTKRY RLQLMDHTWR PYLSQLKVPI PVTPDLDPLT
MLTDDADIAA WQNEGLPADR MSTENATILT SCQRWPLMVD PQLQGIKWIK NKYGEELRVI
RIGQRGYLDA IERALAAGEV VLIENLEETL DPVLGPLLGR ETIKKGRYIK IGDKECEYSP
SFRLILHTKL ASPHYQPELQ AQCTLINFTV TRDGLEDQLL AAVVSMERPD LEELKSDLTK
QQNGFKITLK TLEDNLLSRL SSASGNFLGD TELVENLETT KRTAAEIEEK VKEAKVTEAK
INEAREHYRP AAARASLLYF IMNDLNKIHP MYQFSLKAFS VVFQKAVLKA DPDEALKQRV
SNLIDSITSS VFQYTTRGLF ECDKLTYIAQ LAFQILLMNK EINPAELDFL LRYPVQPGVT
SPVDFLSNHS WGGIKSLCSM DEFRNLDRDI EGSAKRWKKF VESECPEKEK FPQEWKNKSS
LQRLCMMRAL RPDRMTYAVR DFVEEKLGSK YVIGRSLDFA VSFEESGPAT PMFFILSPGV
DPLKDVEKHG KKLGYTFDNK NFHNVSLGQG QEIIAEQALE LAAKNGHWVI LQNIHLVARW
LGTLEKLLEL HAEGSHENFR VFVSAEPSST PEGHIIPQGI LENSIKITNE PPTGMHANLH
KALDNFNQDT LEMCAKENEF KSILFALCYF HAVVAERRKF GPQGWNRSYP FNTGDLTISI
NVLYNYLEAN PKVPYDDLRY LFGEIMYGGH ITDDWDRRLC RTYLEEFIKP EMMEGELYLA
PGFPLPGNMD YNGYHQYIDD TLPGESPYLY GLHPNAEIGF LTQTSEKLFH TVLEMQPRDG
GVGEGGGTTR EEKVRVVLEE IMEKLPEDFN MTELLGKAEE RTPYQVVALQ ECERMNLLTQ
EIRRSLRELI LGLKGELTMT SDMESLQNAI FLDVVPDSWT KRAYPSMCGL ALWFTDLLAR
IKELEAWSTD FVLPSVVWLA GFFNPQSFLT AIMQAMARRN EWPLDSMGLQ CDVTKKNRED
FSSPPREGAY VHGLYMEGAR WDTQTGMIVD ARLKELTPTM PVIFIRAVPV DKQESRNVYQ
CPVYKTCQRG PTYVWTFNLK TKENPSKWTL AGVALLLQI
//
