ID A0A3Q1JYZ2_ANATE Unreviewed; 1108 AA.
AC A0A3Q1JYZ2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Integrin, alpha 1 {ECO:0000313|Ensembl:ENSATEP00000021446.2};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000021446.2, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000021446.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; A0A3Q1JYZ2; -.
DR Ensembl; ENSATET00000021805.2; ENSATEP00000021446.2; ENSATEG00000014601.2.
DR GeneTree; ENSGT00940000157646; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF22; INTEGRIN ALPHA-1; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1068..1092
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 24..82
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 163..349
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 471..533
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 550..608
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 612..672
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1108 AA; 122258 MW; 5AEA194203A62657 CRC64;
DADCREQRRS HLLLACALSF NVDQKNGLSF SGPLEDMFGY TVQQFENSEG KWVLIGSPLS
GQPAKRTGDV YKCPVGKESN TCVKLDLPQN TTVPNLREVK ENMTMGTTLV TNPNGGFLAC
GPQYGYMCGQ QLYISGVCAN VSSSFQILNS VAPGVQECGK ELDIVMVLDG SNSIYPWSSI
VDFLRRFIEN IEIGPKLSQV GIVSYGETVT HRVNLSQFDN TQDLLKFVDD LPQHTGLNTM
TFLGIDTARK EAFMPERGAR PGVKKVMVIV TDGESHDFYK LDKVIGDCEN DGIERFGIAV
LGDYNRGNKS AEEVQKFIKE IESISSQPLR DHFFNVSDEV ALLSIVDALG SRIFALEATT
GNFTSSFEME MSQTGFSAHN SKEGVLLGAV GAYDWNGTVV MHKDGKTITP AKNEFYNPNT
EAGYEQLAGY LGYDVQSAST PNGVLYITGA PRYNHTGRVV IYNLNKNNTV VVSQILKGEQ
IGSYFGSVLQ TVDVDGDSYT DLLLVGAPMY MGSEKNEQGQ VYVYNLNKDN KFEHKFTLKP
VNQSCCTARS DSCTNKNEPC GARFGTAIAA VSDLNLDGFN DVAIGAPFEN DHRGAVYIYH
GDQTSLKEKF VQRIPAGGDG EKVKFFGQSI HGVMDLNGDG ITDVTIGGLG GASLFWSRDV
AELHANMTFN PPKINLQHSQ YQCEHGGRQS VCVTTKVCFF YSIKSDNKDA NSAAGETSIR
FNLTLDALRA KARASFIDED DKNDRRITRN FTIKDTETKC MQETFMMSAR LDFRDALLVS
LEFGLAEDQG PVLDESLPRS INKTSSQRAF YHRLMLPVHD CTLIDVTITV RNSRDNAYNT
KVTLNFTPNI NYVKVEPETG CTLNNTKLEC AVGYPFLGSN AEETFKVKFE VNPKHIQEVI
QINVTATSDL SFGVSSEEPL AVSDTCQPQF RGLYSCTFRH SSVSKQIDPP LYLLSLSLKV
KCSVKDLSNN PDNLKPNTVK ETLSNYLLSC ETLPCASFTC TLSEAKISEV NVTFKVWKPT
FTKGEFSTLN MLVNGVLSIS NTKLFELNDS VKNRTVTIQI SKESLGGIPI WVIIISILIG
LLILALVIFA LWKVTFPDLV HTFQQLIN
//
