ID A0A3Q1K2L3_ANATE Unreviewed; 428 AA.
AC A0A3Q1K2L3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Bone morphogenetic protein 6 {ECO:0000313|Ensembl:ENSATEP00000024476.1};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000024476.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000024476.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3Q1K2L3; -.
DR STRING; 64144.ENSATEP00000024476; -.
DR Ensembl; ENSATET00000024873.2; ENSATEP00000024476.1; ENSATEG00000016989.2.
DR GeneTree; ENSGT00940000158768; -.
DR OMA; ERQQPWP; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19396; TGF_beta_BMP6; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF137; BONE MORPHOGENETIC PROTEIN 6; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..428
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018702984"
FT DOMAIN 308..428
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 288..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 428 AA; 49028 MW; 7D11445FF83E0694 CRC64;
MTSRWFALVG LWWSAYYCMF PVAGSNYSLD GNNEVHPGFM HRRLRTHEKR EMQKEILSIL
GLPHRPRPHL SHGKYNSAPL FMLDLYKTIS GEEKSQVEDM TDRYQSMRTT QSPPLATYQE
TAFLNDADMV MSFVNLVEYD RELSPQRRHH KEFKFNPSQI PEGEAVTAAE FRLYKECMSN
AFHNDTFVLK VYQVVKEHPD READLFLLES RRLWAAQEGW LEFDITASSN LWVMSPVHNL
GLQVSVETSS GQSISFKEAG LVGRDGPLEK QPFMVAFFKV SEVRIRTARS TGGKRRQQNR
NRSTQPQEGS RGPSPADYNS SDQKTACRRH ELYVSFSELG WQDWIIAPEG YAANYCDGEC
SFPLNAHMNA TNHAIVQTLV HLMNPENVPK PCCAPTKLHA ISVLYFDDNS NVILKKYKNM
VVRACGCH
//
