ID   A0A3Q1K3S1_ANATE        Unreviewed;       228 AA.
AC   A0A3Q1K3S1;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Interleukin-6 {ECO:0000256|ARBA:ARBA00019464};
OS   Anabas testudineus (Climbing perch) (Anthias testudineus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX   NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000025421.1, ECO:0000313|Proteomes:UP000265040};
RN   [1] {ECO:0000313|Ensembl:ENSATEP00000025421.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC       {ECO:0000256|ARBA:ARBA00007432}.
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DR   AlphaFoldDB; A0A3Q1K3S1; -.
DR   STRING; 64144.ENSATEP00000025421; -.
DR   Ensembl; ENSATET00000025835.2; ENSATEP00000025421.1; ENSATEG00000017539.2.
DR   GeneTree; ENSGT00390000000878; -.
DR   InParanoid; A0A3Q1K3S1; -.
DR   Proteomes; UP000265040; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR003574; IL-6-like.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR48406; INTERLEUKIN-6; 1.
DR   PANTHER; PTHR48406:SF1; INTERLEUKIN-6; 1.
DR   Pfam; PF00489; IL6; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   3: Inferred from homology;
KW   Acute phase {ECO:0000256|ARBA:ARBA00022486};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..228
FT                   /note="Interleukin-6"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018569247"
FT   REGION          29..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   228 AA;  25288 MW;  073B3ADF443E3096 CRC64;
     FATHLLSAVM LAALLLCAHG APVETALTDN PAGEFSGEGQ VESSNPQNTS TAFTSVLDLT
     VQHKNHFEDE FKNAVSYDSL DDYKPASLPP NCPASNFSKE ACLRRLVEGL QIYTVLLKYV
     ESEFPTSHIK SQTGKLIESL KQKVSLMSLT SVQEEELLKN LNNSKDTYLR KMTAYCILSK
     LHWFVVDGKR AIDKREDKAK SRLRSTSTLV SSFTAYHPVG AHRFLSVS
//