ID A0A3Q1KAA5_ANATE Unreviewed; 837 AA.
AC A0A3Q1KAA5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Guanine nucleotide exchange factor VAV3 {ECO:0000313|Ensembl:ENSATEP00000030646.1};
GN Name=VAV3 {ECO:0000313|Ensembl:ENSATEP00000030646.1};
OS Anabas testudineus (Climbing perch) (Anthias testudineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Anabantaria; Anabantiformes; Anabantoidei; Anabantidae; Anabas.
OX NCBI_TaxID=64144 {ECO:0000313|Ensembl:ENSATEP00000030646.1, ECO:0000313|Proteomes:UP000265040};
RN [1] {ECO:0000313|Ensembl:ENSATEP00000030646.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q1KAA5; -.
DR STRING; 64144.ENSATEP00000030646; -.
DR Ensembl; ENSATET00000031107.2; ENSATEP00000030646.1; ENSATEG00000021154.2.
DR GeneTree; ENSGT00940000155252; -.
DR InParanoid; A0A3Q1KAA5; -.
DR OrthoDB; 2911406at2759; -.
DR Proteomes; UP000265040; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd21264; CH_VAV3; 1.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11978; SH3_VAV3_2; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035734; VAV3_SH3_2.
DR PANTHER; PTHR45818:SF1; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07653; SH3_2; 2.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00109; C1; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265040};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 2..124
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 196..375
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 404..506
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 517..566
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 583..649
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 661..755
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 777..837
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
SQ SEQUENCE 837 AA; 97026 MW; C32663C4587AB1FE CRC64;
MMEYWRQCAL WLINCKVLPA NHRVTWDSAQ VFDLAQTLRD GVLLCHLLNN LKSQSINLKE
INLRPQMSQF LCLKNIRTFL AACSETFGMK KSELFEAFDL FDVRDFGKVM DTLSKLSHTM
LAQQTGIRPF PTEESVEDED IYNHLEDLID ENEVEDEEDL YDCVYNDEEG GEIYEDLMKT
EVAPPPALHK QVETDIRSCC LTEIKQTEEK YTETLESIEK HFMTPLTMYF STAEMEKVFV
NIPDLVKVHK NLLLEIQDSI HHRSAQNLYQ IFITFKERLL IYGRYCSHVE TAIATLDDIC
KNREDVRMKL EECSKRANYG KFTLRDLLVV PMQRVLKYHL LLQELVKHTH DATEKSDLRT
ALDAMKDLAQ YVNEVKRDNE TLREIDQYQK SIENLNHRLT KYGRPKGDGE VRVASVDKRA
KQDRHIFLFD AAVIVCKRRG DIYEMKEVID LHLFKITNNP TSDKENRKWS HGFYLTHNQG
QSGFEFFFKT KELKKKWLEQ FGMAISNIRP ENASNNFHEF RMHTFERITS CNSCHMLLRG
IFNQGYLCSK CGLGAHKECL GRFGSCGKTD PGSVRTQGKE RDPGLPKMLV IRNYFGVPSP
TSGPPLSIQT GDIIELICAD LHSPWWQGKI LSTKEVGFFP SNAVKPCPCV PKPVDYSSQP
WFAGPLERLQ AEAELINRVN STYLVRHRSR EYTEYAISIK YNNDVKHIKI LTKEGCFYIA
ENKKFRSIIE LIEYYKHHSL REGFRSLDTT LQFPYREPEN AAMQRLNRSG GNVFTPKVIG
VAIARYDFSS RDTRELSLQE GDVVKIYTKT GANGWWRGEV NGRVGWFPST YVEEGEE
//
