ID A0A3Q1LFX2_BOVIN Unreviewed; 1013 AA.
AC A0A3Q1LFX2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Folliculin interacting protein 2 {ECO:0000313|Ensembl:ENSBTAP00000057177.1};
GN Name=FNIP2 {ECO:0000313|Ensembl:ENSBTAP00000057177.1,
GN ECO:0000313|VGNC:VGNC:29069};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000057177.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000057177.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057177.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000057177.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057177.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the FNIP family.
CC {ECO:0000256|ARBA:ARBA00007541}.
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DR AlphaFoldDB; A0A3Q1LFX2; -.
DR Ensembl; ENSBTAT00000081446.1; ENSBTAP00000057177.1; ENSBTAG00000011970.6.
DR VEuPathDB; HostDB:ENSBTAG00000011970; -.
DR VGNC; VGNC:29069; FNIP2.
DR GeneTree; ENSGT00390000009391; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000011970; Expressed in cardiac ventricle and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LFX2; baseline and differential.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990877; C:FNIP-folliculin RagC/D GAP; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042030; F:ATPase inhibitor activity; IEA:Ensembl.
DR GO; GO:0051087; F:protein-folding chaperone binding; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0031334; P:positive regulation of protein-containing complex assembly; IEA:Ensembl.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IEA:Ensembl.
DR InterPro; IPR037545; DENN_FNIP1/2.
DR InterPro; IPR028086; FNIP_C_dom.
DR InterPro; IPR026156; FNIP_fam.
DR InterPro; IPR028085; FNIP_mid_dom.
DR InterPro; IPR028084; FNIP_N_dom.
DR PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR Pfam; PF14638; FNIP_C; 2.
DR Pfam; PF14637; FNIP_M; 1.
DR Pfam; PF14636; FNIP_N; 2.
DR PRINTS; PR02073; FOLLICULNIP1.
DR PROSITE; PS51836; DENN_FNIP12; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 60..1013
FT /note="UDENN FNIP1/2-type"
FT /evidence="ECO:0000259|PROSITE:PS51836"
FT REGION 95..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 797..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..704
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 109755 MW; 5B8D7678A41EA2D7 CRC64;
MCGCSARTTA QPRGWRDAAQ GVSDGRLHRT LFCTRTRKHA RVGRSPDAPE LSNSWSCSEL
DLNEIRLIVY QDCERRGRQV LFDSKAVHKM EEMAAQRTED LPAKVPAKSC SGGGPAAHGP
SGGSLPHAKE QLPKYQYTRP ASDVNMLGEM MFGSVAMSYQ GSTLKIHYIR SPPQLMVSKV
FSARMGSFCG STNNLQDSFE YINQDPNLGK LNTNQNNLGP CRTGSNLAHS TPVDMPSRGQ
NEDRDSGIAR SASLSSLLIT PFPSPSSSTS SSSSYQRRWL RSQTTSLENG IIPRRSMDET
FSLAEETCSS NPAIVRRKKI AISIIFSLCE KEEAQRNFQD FFFSHFPLFE SHMNRLKSAI
EKAMISCRKI AESSLRVQFY VSRLMEALGE FRGTIWSLYS VPRIAEPVWL AMMSSTLERT
QLCQRFLKEF TLLIEQINKN QFFAALLTAV LTYHLAWVPT VMPVDHPPIK AFSEKRTSQL
VNMLAKTHPY NPLWAQLGDL YGAIGSPVRL TRTVVLGKQK DLVQRILYVL TYFVRCSELQ
ENQLMWSGGP AQGEQILHGS SITTALERGE VEESEYVVVT VRSEPALLPP TLPVTTAEGL
AGVPVDADPR DLCPQLDGEG GGALEKSLTA HGAWRPQGVS CGEEESKEPP RGGSARLPSG
AGVGAGLKMS PPAIGAEPGG EMPKRLPDRS AARPCPDGRL RDRPPWEKVT FHIGSSVSPE
SDFESRTKAM EERLQACRCA EPEPAQGPLA GPGAAADPAQ EGQDQCTLMC SRSPGVSGVG
RDVRTEAAVE VAGALGAPAT PCAPASPAGA PARPGGQRGK DADALVTSGC TTPVPSGDAG
FRVEGGLPRN ESSDSALGDS DDDTCAAASP DLGPGSDPDA DHDQSEGSLE VELPLPRSQS
ISNPNVRNFG RSLLAGYCPT YMPDLVLHGT SSDEKLKQCL AADLVHTVQC VMHLEDRLQE
MYLKSKMLSE YLRGHTRVHV KELSVVLGIE SNDLPLLTAI ASTHSPYVAQ ILL
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