ID A0A3Q1LFZ6_BOVIN Unreviewed; 457 AA.
AC A0A3Q1LFZ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Tropomyosin 1 {ECO:0000313|Ensembl:ENSBTAP00000057222.1};
GN Name=TPM1 {ECO:0000313|Ensembl:ENSBTAP00000057222.1,
GN ECO:0000313|VGNC:VGNC:106994};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000057222.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000057222.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057222.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000057222.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057222.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the tropomyosin family.
CC {ECO:0000256|ARBA:ARBA00009036, ECO:0000256|RuleBase:RU004515}.
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DR AlphaFoldDB; A0A3Q1LFZ6; -.
DR Ensembl; ENSBTAT00000072971.1; ENSBTAP00000057222.1; ENSBTAG00000005373.6.
DR VEuPathDB; HostDB:ENSBTAG00000005373; -.
DR VGNC; VGNC:106994; TPM1.
DR GeneTree; ENSGT01030000234542; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000005373; Expressed in biceps femoris and 106 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LFZ6; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.370; -; 1.
DR InterPro; IPR000533; Tropomyosin.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR19269; TROPOMYOSIN; 1.
DR PANTHER; PTHR19269:SF41; TROPOMYOSIN 1; 1.
DR Pfam; PF00261; Tropomyosin; 1.
DR PRINTS; PR00194; TROPOMYOSIN.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS00326; TROPOMYOSIN; 1.
PE 1: Evidence at protein level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A3Q1LFZ6};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT REGION 88..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 216..446
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 457 AA; 49150 MW; 73B1D140FF769E4E CRC64;
MSLEGRRVAG LGSGVLGFFT VPLGTHLSPK PLARLLSLLG RDLAVRSGAL PPPVGGTVAP
CSQIRYSGFS AAPGRGAGSP SNILGAVGPR SPAHLVPPQR APRPSAGQPR ARAVPPATGE
FPGSAARDPP RPLGPPPALA HPLAVRLSFP GGRDFRAEPG PQGAPPSRAA AWAGRAVGRS
AAAAAAAGAQ QPASPTAARP LAGPPPLGAM AGSSSLEAVR RKIRSLQEQA DAAEERAGSL
QRELDYERKL RETAEADVAS LNRRIQLVEE ELDRAQERLA TALQKLEEAE KAADESERGM
KVIESRAQKD EEKMEIQEIQ LKEAKHIAED ADRKYEEVAR KLVIIESDLE RAEERAELSE
GKCAELEEEL KTVTNNLKSL EAQAEKYSQK EDKYEEEIKV LSDKLKEAET RAEFAERSVT
KLEKSIDDLE EKVAHAKEEN LSMHQMLDQT LLELNNM
//
