ID A0A3Q1LID2_BOVIN Unreviewed; 1166 AA.
AC A0A3Q1LID2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Adhesion G protein-coupled receptor G6 {ECO:0000313|Ensembl:ENSBTAP00000058762.1};
GN Name=ADGRG6 {ECO:0000313|Ensembl:ENSBTAP00000058762.1,
GN ECO:0000313|VGNC:VGNC:25669};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000058762.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000058762.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058762.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000058762.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058762.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; A0A3Q1LID2; -.
DR Ensembl; ENSBTAT00000085167.1; ENSBTAP00000058762.1; ENSBTAG00000020707.5.
DR VEuPathDB; HostDB:ENSBTAG00000020707; -.
DR VGNC; VGNC:25669; ADGRG6.
DR GeneTree; ENSGT00940000155621; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000020707; Expressed in thymus and 85 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LID2; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF290; ADHESION G-PROTEIN COUPLED RECEPTOR G6; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..1166
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018666794"
FT TRANSMEM 837..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..892
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..929
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 941..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1020
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1060
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1066..1088
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..148
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 835..1089
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1127..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 93..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 1166 AA; 130237 MW; 04202FE45153C58D CRC64;
MFHSDRMWSC HWKWKPSSLL FLFALCLVYA PLSVWACANC RVVLSNPSGT FTSPCYPNDY
PNSQACMWTL RAPTGYIIQI TFNDFDIEEA PNCIYDSLSL DNGESQTKFC GATAKGLSFN
SSVNEMHVSF SSDFSIQKKG FNASYVRVAV SLRNQKVILP QSLDSYQVSV AKSVSIPELR
AFTLCFEATK IGKEDSEWTA FSYSDASFPQ LLSFGKTKSG YFLSFFGSKC LLNSALPVKD
KEDIFTESFE QLCIAWSSSL GSVGVNFKRN YGTVSCNSSM GKVIPGNGKL LLGSNQHDIG
SLKGDIYNFR LWNFTISSKI LSNLSCSVKG NVVDWQNDFW NIPTLALKAE SNLSCGSYLI
PLPAAELASC ADLGTLCQDG IIYRISIVLQ NILPHPEVKV QSKVAEWLNS TFQNWNYTVY
VVNISFHLST GEDKIKVRRS VVTDQRLVIL ALLVYNATNN PTLEGRTIQQ KLLRNNESLD
EGLRLHKVNV RQLGVCHADE KPKGYKWPSI QPSEYRTPCL GKPGFFASRT CYDDPNNTSV
AIWGLPDISN CSREANEVAN EILNLTSDGQ TLSSANITSI VEKVKRIVNE KENIDITLGS
TLMNIFSNIL TSPDSDLLES SSEALKTIDE LAFKIDLQST THMNITTQNL ALGVSSVSPE
TNEVSNFSIG LPSNNESYFQ MDFKSGQMDP LASVILPPNL LKNLSEEDSV LVKRAQFTFF
NKTGLFQDVG TKKGTLVSYV MACSIGNITI QGLKDPVQIK IKHTRTQAMA HPICAFWDLN
KNESSGFWNT SGCVAHKDSD ANETVCLCNH LTHFGVLMDL QGTASQLDAK NTKILTFITY
IGCGISAIFS AATLLTYVAF EKLRRDYPSK ILMNLSTALL FLNLVFLLDR WITSFHVDGL
CTAIAALLHF FLLAAFTWMG LEAIHMYIAL VKVFNTYIRR YILKFCIVGW GVPILVVSIV
LASRKQNEVY GKKSYGREQG DEFCWIQDPV VFYVTCAGYF GLMFFLNVAM FIVVMVQICG
RNGKRSSRTL REEVLRNLRS VVSLTFLLGM TWGFSFFAWG PLNVPFMYLF SIFNSLQGLF
IFIFHCAMKE NVQKQWRRHL CCGRFRLADN SDWSKTATNI IKKSSDNLGK SLSSSSIGSN
STYLTSKSKS SSTTYFKRNS HTDNVF
//
