ID A0A3Q1LIV0_BOVIN Unreviewed; 707 AA.
AC A0A3Q1LIV0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Zona pellucida sperm-binding protein 2 {ECO:0000256|ARBA:ARBA00040237};
DE AltName: Full=Zona pellucida glycoprotein 2 {ECO:0000256|ARBA:ARBA00042572};
DE AltName: Full=Zona pellucida protein A {ECO:0000256|ARBA:ARBA00042272};
GN Name=ZP2 {ECO:0000313|Ensembl:ENSBTAP00000059112.1,
GN ECO:0000313|VGNC:VGNC:37366};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000059112.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000059112.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059112.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000059112.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059112.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Zona pellucida
CC {ECO:0000256|ARBA:ARBA00024183}.
CC -!- SIMILARITY: Belongs to the ZP domain family. ZPA subfamily.
CC {ECO:0000256|ARBA:ARBA00038403}.
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DR AlphaFoldDB; A0A3Q1LIV0; -.
DR Ensembl; ENSBTAT00000074062.1; ENSBTAP00000059112.1; ENSBTAG00000011504.5.
DR VEuPathDB; HostDB:ENSBTAG00000011504; -.
DR VGNC; VGNC:37366; ZP2.
DR GeneTree; ENSGT00940000160133; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000011504; Expressed in oocyte and 52 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LIV0; baseline.
DR GO; GO:0035805; C:egg coat; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007338; P:single fertilization; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.4100; Zona pellucida, ZP-C domain; 1.
DR Gene3D; 2.60.40.3210; Zona pellucida, ZP-N domain; 1.
DR InterPro; IPR042235; ZP-C.
DR InterPro; IPR048290; ZP_chr.
DR InterPro; IPR001507; ZP_dom.
DR InterPro; IPR017977; ZP_dom_CS.
DR PANTHER; PTHR23343; ZONA PELLUCIDA SPERM-BINDING PROTEIN; 1.
DR PANTHER; PTHR23343:SF4; ZONA PELLUCIDA SPERM-BINDING PROTEIN 2; 1.
DR Pfam; PF00100; Zona_pellucida; 1.
DR PRINTS; PR00023; ZPELLUCIDA.
DR SMART; SM00241; ZP; 1.
DR PROSITE; PS00682; ZP_1; 1.
DR PROSITE; PS51034; ZP_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Fertilization {ECO:0000256|ARBA:ARBA00023279};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 396..662
FT /note="ZP"
FT /evidence="ECO:0000259|PROSITE:PS51034"
SQ SEQUENCE 707 AA; 79234 MW; AAC12BF0F12AD7AF CRC64;
MQAERRQRET LKLVPCRLEV FLGAERRGQN ALSAEVHSSL TFSPMSSCTY RSFFLSFTLL
TSVNSIDVNQ LDPAFPGTVT CYENRMVVEF KRTLGNKIQH ASVVDSLGLK MLNCTYVLDP
EKLTLKAPYE SCTKRVLGQH QMTITFMNDN TAHRQKTVLY HVSCPVMQAG RHDQHSGSTI
CSKDFMSFTF HFFPGLADDT AGPKPQMGWT VTVGDGERAQ NLTLQEALTQ GYNLLIENQK
MSIQVLFHAT GVTHYSQGNS HLYMVPLKLT HVSPGQTIIL SSRLLCASDP VTCNATHMTL
TIPEFPGKLK SVSFENKNIA VNQLHNSGIV MEIANGLRLH FSKTLLKTKF SEKCLPYQFY
LSSLKLTFYT QLETVSMVIY PECVCESTVS IVSGELCTQD GFMDVEVYHH QTKPALNLDT
LRVGDSSCQP TIKAPFQGLV KFHIPLNGCG TRHKFENGKV IYENEIHALW ADLPPSTISR
DSEFRMTVRC YYSSSNMLIN TNVESLPPPV ASVKPGPLAL TLQTYPDNSY LQPYGDKDYP
VVRYLRQPIY LEVRVLNRTD PNIKLVLDDC WATSTMDPAS LPQWNIIVDG CEYNLDNHRT
TFHPVGSSVA YPNHYQRFAV KTFAFVSEDP AFSHLVYFHC SALICDQLSS NFPLCSASCL
VSSRSRRATG ATEEEKMIVS LPGPILLLSD GSSFRATNCK KSCTWDY
//
