ID A0A3Q1LJK4_BOVIN Unreviewed; 1160 AA.
AC A0A3Q1LJK4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Fibulin 2 {ECO:0000313|Ensembl:ENSBTAP00000059623.1};
GN Name=FBLN2 {ECO:0000313|Ensembl:ENSBTAP00000059623.1,
GN ECO:0000313|VGNC:VGNC:28882};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000059623.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000059623.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059623.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000059623.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059623.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibulin family.
CC {ECO:0000256|ARBA:ARBA00006127}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_015315190.1; XM_015459704.1.
DR RefSeq; XP_015324299.1; XM_015468813.1.
DR AlphaFoldDB; A0A3Q1LJK4; -.
DR PaxDb; 9913-ENSBTAP00000005240; -.
DR Ensembl; ENSBTAT00000082158.1; ENSBTAP00000059623.1; ENSBTAG00000004014.6.
DR GeneID; 511854; -.
DR CTD; 2199; -.
DR VEuPathDB; HostDB:ENSBTAG00000004014; -.
DR VGNC; VGNC:28882; FBLN2.
DR GeneTree; ENSGT00940000156047; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000004014; Expressed in ureter and 102 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LJK4; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF196; RE64043P; 1.
DR Pfam; PF01821; ANATO; 2.
DR Pfam; PF12662; cEGF; 2.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF14670; FXa_inhibition; 1.
DR SMART; SM00104; ANATO; 3.
DR SMART; SM00181; EGF; 11.
DR SMART; SM00179; EGF_CA; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS01187; EGF_CA; 3.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1160
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018695245"
FT DOMAIN 421..456
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 464..495
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 497..529
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT DOMAIN 580..621
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 834..876
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 877..918
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 268..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 618..643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1160 AA; 124034 MW; 59934FA5B0E697A1 CRC64;
MARLGEPMGA WLALALALAL SPGGAAAPGQ DCTGVECPPL ENCIEDALEP GACCATCVQR
GCACEGYQYY DCLQGGFVRG RVPAGQSYFV DFGSTECSCP PGGGKISCQF MPCPELPPNC
IEAVVAADSC PQCGQVGCVH SGRKYAAGHT VRLAPCRACH CPDAGGELIC YPLPDCHGDA
APGNTSDAED GDPERHYEDP YSYDQEVAEA EALAGELQAG AGGPAALGGG GQPPSALQAT
LWPAALPRPT AAAALGPPAP VQAKARRVTD DGQEDREVPA VQEQLAAGGP RGLDGRPTAG
PMPAHPVREE GAEARAGVEE NLIPDVQATH RSAGPPPTFS MPNILLTETT QGPPEAPTEP
SAHAALTTLQ QETARAPPTQ EVPQQPAGPR SRLEEEEDPN SVHSVPRAGL EVSTKDLIET
CCAAGQQWAI DSDECLDIPE SGAEGDACRT AQKQCCVSYL KEKSCMAGVL GAKEGEACGD
EDSDTCGVSL YKQCCDCCGL GLRVRAEGQS CESNPNLGYP CNHVMLSCCE GEDPLIVPEV
RRPPEPEAVP RRVSEAELAS REALSLGTET ELPNSLPGDD QDECLLLPGE LCQHLCINTV
GSYRCACFPG FSLQDDGRTC RPEGAPPKPE AAEESAQRPE SAQVAPNTIA LPVPQPNTCQ
DNGPCKQVCR VVGDTAMCSC FPGYAIMADG VSCEDINECV TDLHTCSRRE HCVNTVGSFH
CYKALTCEPG YRLEDGECTD VDECELGTHN CQAGAVCHNT KGSFYCQARQ RCLEGFLQDP
EGNCVDINEC TSLSEPCRPG FSCINTVGSY TCQRNPVICG RGYHASQDGT KCVDVNECET
GVHRCGEGQV CHNLPGSYRC DCKPGFQRDA FGRTCIDVNE CWTSPTRLCQ HTCENTLGSY
RCSCASGFLL AADGKHCEDV NECEAQRCSQ ECANIYGSYQ CYCRQGYQLA EDGHTCTDID
ECAQGASILC TFRCINVPGS YQCTCPERGY TMTANGRSCK DLDECALGTH NCSEAETCHN
IQGGFRCLRF DCPPNYVRVS ETKCERALCH DFLECQNAPA RITHYRLNFQ TGLLVPAHIF
RISPVPAFAG DTIALTITKG NEEGYFGTRR LNAYTGVVFL QRTVREPRDF ALDVEMKLWR
QGSVTTFLAK MHIFFTAFAL
//