ID A0A3Q1LK34_BOVIN Unreviewed; 379 AA.
AC A0A3Q1LK34;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Interleukin 3 receptor subunit alpha {ECO:0000313|Ensembl:ENSBTAP00000056952.1};
GN Name=IL3RA {ECO:0000313|Ensembl:ENSBTAP00000056952.1,
GN ECO:0000313|VGNC:VGNC:106780};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056952.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000056952.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056952.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000056952.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056952.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q1LK34; -.
DR SMR; A0A3Q1LK34; -.
DR STRING; 9913.ENSBTAP00000056952; -.
DR Ensembl; ENSBTAT00000085850.1; ENSBTAP00000056952.1; ENSBTAG00000049808.1.
DR VEuPathDB; HostDB:ENSBTAG00000049808; -.
DR VGNC; VGNC:106780; IL3RA.
DR GeneTree; ENSGT00940000163802; -.
DR InParanoid; A0A3Q1LK34; -.
DR OMA; TATCNKS; -.
DR OrthoDB; 5353959at2759; -.
DR Reactome; R-BTA-512988; Interleukin-3, Interleukin-5 and GM-CSF signaling.
DR Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-BTA-912526; Interleukin receptor SHC signaling.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000049808; Expressed in lung and 97 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.3850; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040907; IL3Ra_N.
DR InterPro; IPR015321; TypeI_recpt_CBD.
DR Pfam; PF18611; IL3Ra_N; 1.
DR Pfam; PF09240; IL6Ra-bind; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..379
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018564215"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..100
FT /note="IL-3 receptor alpha chain N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18611"
FT DOMAIN 111..202
FT /note="Type I cytokine receptor cytokine-binding"
FT /evidence="ECO:0000259|Pfam:PF09240"
SQ SEQUENCE 379 AA; 43312 MW; 40A4BB4CD95F37DE CRC64;
MALPWLAVLL TLICCSMTTD HAISDPDPPI KNLRIDPERK RLAWDQHGNV SEIGCYVNSK
ILKKAIEKPY CSLGDLSCEV KNYTVKVIKG QPFSAWIQYP KQGNPLAAAD NLTCRVHDVD
QLSCSWAVGE EAPANVQYHF YLKHPLKTWP CPKYMQNQQG VNVQCHFDSL SLQPERQTLF
RFLVNGTSGG SKIPCRQMTH RLEEIEILAA PNITKKWCNE SYSFMEWEVR SLFTEDIKYE
LEIQKGTDLA YKEETELKVL GLRNPGPYTV KIKAMDSLFF ESRPAGQWSA PQHLDCGRKD
ASFPIWLVYL LAPLGALLLV GLVFLCRRWP LMQKLFPRVP HVKDPVGDSF QNERMMAWDP
EQQSQEECPV VRVQVLGET
//
