ID A0A3Q1LKC4_BOVIN Unreviewed; 117 AA.
AC A0A3Q1LKC4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Stromal cell-derived factor 1 {ECO:0000256|ARBA:ARBA00016440};
DE AltName: Full=C-X-C motif chemokine 12 {ECO:0000256|ARBA:ARBA00033206};
GN Name=CXCL12 {ECO:0000313|Ensembl:ENSBTAP00000059999.1,
GN ECO:0000313|VGNC:VGNC:27848};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000059999.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000059999.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059999.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000059999.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000059999.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC {ECO:0000256|ARBA:ARBA00010665}.
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DR RefSeq; XP_005226673.1; XM_005226616.1.
DR AlphaFoldDB; A0A3Q1LKC4; -.
DR Ensembl; ENSBTAT00000083508.1; ENSBTAP00000059999.1; ENSBTAG00000005077.5.
DR GeneID; 613811; -.
DR CTD; 6387; -.
DR VEuPathDB; HostDB:ENSBTAG00000005077; -.
DR VGNC; VGNC:27848; CXCL12.
DR GeneTree; ENSGT00390000014056; -.
DR Proteomes; UP000009136; Chromosome 28.
DR Bgee; ENSBTAG00000005077; Expressed in ureter and 108 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LKC4; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00273; Chemokine_CXC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR039809; Chemokine_b/g/d.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR033899; CXC_Chemokine_domain.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR PANTHER; PTHR12015; SMALL INDUCIBLE CYTOKINE A; 1.
DR PANTHER; PTHR12015:SF206; STROMAL CELL-DERIVED FACTOR 1; 1.
DR Pfam; PF00048; IL8; 1.
DR PRINTS; PR00436; INTERLEUKIN8.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..117
FT /note="Stromal cell-derived factor 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018687707"
FT DOMAIN 27..86
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 117 AA; 12712 MW; 2883FEBDD7F9D7AC CRC64;
MDAKVFVVLA LVLTALCLSD AKPVSLSYRC PCRFFESHVA KANVKHLKIL NTPNCSLQIV
ARLKNNNRQV CIDPKLKWIQ EYLDKALNKP SPTLSGLTSA LGTDPARTTV GVTSSGS
//
