ID A0A3Q1LNV5_BOVIN Unreviewed; 510 AA.
AC A0A3Q1LNV5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Acid sensing ion channel subunit 2 {ECO:0000313|Ensembl:ENSBTAP00000058527.1};
GN Name=ASIC2 {ECO:0000313|Ensembl:ENSBTAP00000058527.1,
GN ECO:0000313|VGNC:VGNC:26211};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000058527.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000058527.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058527.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000058527.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000058527.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q1LNV5; -.
DR Ensembl; ENSBTAT00000075976.1; ENSBTAP00000058527.1; ENSBTAG00000025200.5.
DR VEuPathDB; HostDB:ENSBTAG00000025200; -.
DR VGNC; VGNC:26211; ASIC2.
DR GeneTree; ENSGT00940000154991; -.
DR Proteomes; UP000009136; Chromosome 19.
DR Bgee; ENSBTAG00000025200; Expressed in Ammon's horn and 70 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LNV5; baseline.
DR GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
DR GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:Ensembl.
DR GO; GO:0050974; P:detection of mechanical stimulus involved in sensory perception; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0007602; P:phototransduction; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0035418; P:protein localization to synapse; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0034765; P:regulation of monoatomic ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0003026; P:regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback; IEA:Ensembl.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:Ensembl.
DR GO; GO:0010447; P:response to acidic pH; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR GO; GO:0050915; P:sensory perception of sour taste; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR Gene3D; 1.10.3590.10; acid-sensing ion channel 1 domain; 2.
DR Gene3D; 1.10.287.820; Acid-sensing ion channel domain; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF128; ACID-SENSING ION CHANNEL 2; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022461}.
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 510 AA; 57063 MW; 5B9DF6A6350B5C21 CRC64;
MSRSGGAGRP AAALTGPGRF RMAREEPAPA AVAAAGQPGG GRGGERERAL QGPGGARRGR
PSLSRAKLHG LRHMCAGRAA PGGSFQRRAL WVLAFCTSLG LLLSWSSNRL LYWLSFPSHT
RVHREWSRQL PFPAVTVCNN NPLRFPRLSK GDLYYAGHWL GLLLPNRTAR PLVSELLRGD
EPRRQWFRKL ADFRLFLPPR HFEGISAAFM DRLGHQLEDM LLSCKYRGEL CGPHNFSSVF
TKYGKCYMFN SGEDGKPLLT TVKGGTGNGL EIMLDIQQDE YLPIWGETEE TTFEAGVKVQ
IHSQSEPPFI QELGFGVAPG FQTFVATQEQ RLTYLPPPWG ECRSSEMGLD FFPVYSITAC
RIDCETRYIV ENCNCRMVHM PGDAPFCTPE QHKECAEPAL GLLAEKDSNY CLCRTPCNLT
RYNKELSMVK IPSKTSAKYL EKKFNKSEKY ISENILVLDI FFEALNYETI EQKKAYEVAA
LLGDIGGQMG LFIGASILTI LELFDYIYEV
//