ID A0A3Q1LQ12_BOVIN Unreviewed; 994 AA.
AC A0A3Q1LQ12;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Erythrocyte membrane protein band 4.1 like 2 {ECO:0000313|Ensembl:ENSBTAP00000057051.1};
GN Name=EPB41L2 {ECO:0000313|Ensembl:ENSBTAP00000057051.1,
GN ECO:0000313|VGNC:VGNC:28521};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000057051.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000057051.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057051.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000057051.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000057051.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_010797261.1; XM_010798959.2.
DR RefSeq; XP_010806866.1; XM_010808564.2.
DR AlphaFoldDB; A0A3Q1LQ12; -.
DR PaxDb; 9913-ENSBTAP00000007823; -.
DR Ensembl; ENSBTAT00000086113.1; ENSBTAP00000057051.1; ENSBTAG00000005960.6.
DR GeneID; 538959; -.
DR CTD; 2037; -.
DR VEuPathDB; HostDB:ENSBTAG00000005960; -.
DR VGNC; VGNC:28521; EPB41L2.
DR GeneTree; ENSGT00940000155617; -.
DR OrthoDB; 5391231at2759; -.
DR Proteomes; UP000009136; Chromosome 9.
DR Bgee; ENSBTAG00000005960; Expressed in retina and 104 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LQ12; baseline and differential.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR CDD; cd17202; FERM_F1_EPB41L2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF17; BAND 4.1-LIKE PROTEIN 2; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PIRSF; PIRSF002304; Membrane_skeletal_4_1; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 206..487
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..57
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 718..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..838
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 994 AA; 111079 MW; 0E3CA91266DDDFF9 CRC64;
MTTEVGSASE VKKESDQLGA DATKEKPKEV AENQQNQTSD PEEEKGSQSS PPAESQSSPR
RQKKEKDPSE SRGISRFIPP WLKKQKSYTL VAAKDGGDKK EPAQPVVGEQ VLDKEESLPE
EERRAKGDAE ETAQRKQQEI KVDVKEEKPL QLVEEVSKER EEEKVKEIQE AEFMDEAAKR
ETKEVQTNEL RAEKASLKAP KKTKTVQCKV TLLDGSEYSC DLEKRAKGQV LFDKVCEHLN
LLEKDYFGLV FQENPEQKNW LDPAKEIKRQ LRNLPWLFSF NVKFYPPDPS QLTEDITRYF
LCLQLRQDIA SGRLPCSFVT HALLGSYTLQ AELGDYDPEE HASHDLSDFQ FAPTQTKELE
EKVAELHKTH RGLSPAQADS QFLENAKRLS MYGVDLHHAK DSEGVDIKLG VCANGLLIYK
DRLRINRFAW PKILKISYKR SNFYIKVRPA ELEQFESTIG FKLPNHRAAK RLWKVCVEHH
TFYRLVSPEQ PPKAKFLTLG SKFRYSGRTQ AQTRQASSLI DRPAPHFERT SSKRVSRSLD
GAPIDAVDQS LMKDFPGPAG EVSAPGPGVV STAVVQDGDG RRDLRSPAKV PHMPLIEGKK
NSLRVEGDNI YVRHSNLMLE DLDKAQEEIL KHQASISELK RNFMESTPEP RPNEWEKRRI
TPLSLQTQGS SLETLNVVEE KKQAEVGKDE RVIPEEMNGK ELSPGRGPGE MRKVEPGTQK
DSTSLSSESS SSSSESEEEE DVGEYRPHHR VTEGTIREEQ EEDEEEVEEA PGQAAKVVDR
EDPVPAASPV THAGASVGPV ETVPQEKVVA PQIPAEKSVN EGAVKQDTGE ETEEEPQKVN
GEVAHVDTDV LPQIICCSEP PVVKTEMVTI SDASQRTEIS TKEVPIVQTE TKTITYESPQ
IDGGAGGDSG TLLTAQTITS ESVSTTTTTH ITKTVKGGIS ETRIEKRIVI TGDADIDHDQ
ALAQAIREAR EQHPDMSVTR VVVHKETELE EGEE
//
