ID A0A3Q1LRF2_BOVIN Unreviewed; 1271 AA.
AC A0A3Q1LRF2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=UPF2 regulator of nonsense mediated mRNA decay {ECO:0000313|Ensembl:ENSBTAP00000062840.1};
GN Name=UPF2 {ECO:0000313|Ensembl:ENSBTAP00000062840.1,
GN ECO:0000313|VGNC:VGNC:36681};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000062840.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000062840.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000062840.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000062840.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000062840.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_001249612.3; XM_001249611.7.
DR RefSeq; XP_002692096.2; XM_002692050.5.
DR RefSeq; XP_003582946.1; XM_003582898.3.
DR RefSeq; XP_003586795.1; XM_003586747.3.
DR AlphaFoldDB; A0A3Q1LRF2; -.
DR SMR; A0A3Q1LRF2; -.
DR STRING; 9913.ENSBTAP00000062840; -.
DR PaxDb; 9913-ENSBTAP00000053336; -.
DR Ensembl; ENSBTAT00000075557.1; ENSBTAP00000062840.1; ENSBTAG00000000288.7.
DR GeneID; 781181; -.
DR KEGG; bta:781181; -.
DR CTD; 26019; -.
DR VEuPathDB; HostDB:ENSBTAG00000000288; -.
DR VGNC; VGNC:36681; UPF2.
DR GeneTree; ENSGT00530000064318; -.
DR InParanoid; A0A3Q1LRF2; -.
DR OMA; DFQHHQI; -.
DR OrthoDB; 276824at2759; -.
DR Reactome; R-BTA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000009136; Chromosome 13.
DR Bgee; ENSBTAG00000000288; Expressed in spermatid and 107 other cell types or tissues.
DR ExpressionAtlas; A0A3Q1LRF2; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0035145; C:exon-exon junction complex; IBA:GO_Central.
DR GO; GO:0005844; C:polysome; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:Ensembl.
DR GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR Gene3D; 1.25.40.180; -; 3.
DR Gene3D; 4.10.80.160; -; 1.
DR Gene3D; 6.10.250.770; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR039762; Nmd2/UPF2.
DR InterPro; IPR007193; Upf2/Nmd2_C.
DR PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR Pfam; PF02854; MIF4G; 3.
DR Pfam; PF04050; Upf2; 1.
DR SMART; SM00543; MIF4G; 3.
DR SUPFAM; SSF48371; ARM repeat; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 167..363
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 568..757
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 772..985
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1017..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1219..1271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1024..1077
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1096
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1271 AA; 147863 MW; D1566AEE92FBAD6C CRC64;
MPAERKKPAS MEEKESSLNS KEKDCSERRP VSSREKPKEE IKLTAKKEVI KVPEDKKKKL
EEDKRKKEDK ERKKKEEEKV KAEEELKKKE EEEKKKHEEE ERKKQEEQVK RQQEEEAAQL
KEKEESLQLH QEAWERHQLR KELRSKNQNA PDNRPEENFF SRLDSSLKKN TAFVKKLKTI
TEQQRDSLSH DFNGLNLSKY IAEAVASIVE AKLKISDVNC AVHLCSLFHQ RYADFAPSLL
QVWKKHFEAR KEEKTPNITK LRTDLRFIAE LTIVGIFTDK EGLSLIYEQL KNIINADRES
HTHVSVVISF CRHCGDDIAG LVPRKVKSAA EKFNLSFPPS EIISPEKQQP FQNLLKEYFT
SLTKHLKRDH RELQNTERQN RRILHSKGEL SEDRHKQYEE FAMSYQKLLA NSQSLADLLD
ENMPDLPQDK PTPEEHGPGI DIFTPGKPGE YDLEGGIWED EDARNFYENL IDLKAFVPAI
LFKDNEKSCQ NKESSKDDSK ETKEPKDNKE VSSPDDLELE LENLEINDDT LELEGGDEAE
DLTKKLLDEQ EQEDEEASTG SHLKLIVDAF LQQLPNCVNR DLIDKAAMDF CMNMNTKANR
KKLVRALFIV PRQRLDLLPF YARLVATLHP CMSDVAEDLC SMLRGDFRFH VRKKDQINIE
TKNKTVRFIG ELTKFKMFTK NDTLHCLKML LSDFSHHHIE MACTLLETCG RFLFRSPESH
LRTSVLLEQM MRKKQAMHLD ARYVTMVENA YYYCNPPPAE KTVKKKRPPL QEYVRKLLYK
DLSKVTTEKV LRQMRKLPWQ DQEVKDYVIC CMINIWNVKY NSIHCVANLL AGLVLYQEDV
GIHVVDGVLE DIRLGMEVNQ PKFNQRRISS AKFLGELYNY RMVESAVIFR TLYSFTSFGV
NSDGSPSSLD PPEHLFRIRL VCTILDTCGQ YFDRGSSKRK LDCFLVYFQR YVWWKKSLEV
WTKDHPFPID IDYMISDTLE LLRPKIKLCN SLEESIRQVH DLEREFLIKL GLVNDKDSKD
SMTEGENLEE DEEEEEGGAE TEEQSGNESE VNEPEEEEGS DNDDDEGEEE EEENTDYLTD
SNKENETDEE NTEVMIKGGG LKHVPCVEDE DFIQALDKMM LENLQQRSGE SVKVHQLDVA
IPLHLKSQLR KGPPLGGGEG ETESADTMPF VMLTRKGNKQ QFKILNVPMS SQLAANHWNQ
QQAEQEERMR MKKLTLDINE RQEQEDYQEM LQSLAQRPAP ANTNRERRPR YQHPKGAPNA
DLIFKTGGRR R
//
